Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 8/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 6/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356985 | 0.89 | EGLN3 (0.43) | EGLN3EGLN1EGLN2PTGDR2 | |
| SCHEMBL4359892 | 0.88 | EGLN3 (0.59) | EGLN3EGLN1EGLN2CYSLTR2GCGR | |
| SCHEMBL4359368 | 0.87 | EGLN3 (0.43) | EGLN3EGLN1EGLN2CYSLTR2 | |
| SCHEMBL4364439 | 0.87 | EGLN3 (0.46) | EGLN3EGLN1EGLN2CYSLTR2PTGDR2 | |
| SCHEMBL4368360 | 0.86 | EGLN3 (0.41) | EGLN3EGLN1EGLN2PTGDR2 | |
| SCHEMBL3856415 | 0.85 | EGLN3 (0.48) | EGLN3EGLN1EGLN2CYSLTR2GCGR | |
| SCHEMBL4358358 | 0.84 | EGLN3 (0.45) | EGLN3EGLN1EGLN2CYSLTR2PTGDR2 | |
| SCHEMBL4364331 | 0.83 | HIF1A (0.43) | EGLN3EGLN1 | |
| SCHEMBL4367648 | 0.82 | EGLN1 (0.44) | EGLN3EGLN1EGLN2 | |
| SCHEMBL4357034 | 0.80 | EGLN3 (0.49) | EGLN3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |