Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | CBFB | Q13951 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460724 | 0.83 | STAT3 (0.59) | STAT3STAT1CCR1CCR5CCR8 | |
| SCHEMBL599432 | 0.82 | CCR1 (0.50) | CCR1CCR5CCR8METAP2TERT | |
| SCHEMBL4359482 | 0.81 | CCR1 (0.42) | STAT3STAT1CCR1CCR5CCR8 | |
| SCHEMBL9582368 | 0.79 | STAT3 (0.57) | STAT3STAT1METAP2METAP1CBFB | |
| SCHEMBL6411259 | 0.79 | STAT3 (0.53) | STAT3STAT1TERT | |
| SCHEMBL6537531 | 0.79 | STAT3 (0.32) | STAT3STAT1CCR1CCR5CCR8 | |
| SCHEMBL30205816 | 0.79 | STAT3 (0.64) | STAT3STAT1TERT | |
| SCHEMBL5319095 | 0.79 | STAT3 (0.64) | STAT3STAT1TERT | |
| SCHEMBL16649288 | 0.78 | STAT3 (0.32) | STAT3STAT1CCR1CCR5CCR8 | |
| SCHEMBL16268025 | 0.78 | STAT3 (0.32) | STAT3STAT1CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1093373-A4 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | UNIV COLUMBIA (US) | 2005-04-13 | — | — | EP | claimed |
| US-20030017196-A1 | Oligonucleotide inhibitors of bcl-xL | ARONEX PHARMACEUTICALS, INC. | 2003-01-23 | — | — | US | claimed |
| US-20020098231-A1 | Oligonucleotide inhibitors of bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2002-07-25 | — | — | US | claimed |
| EP-1093373-A1 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2001-04-25 | — | — | EP | claimed |
| WO-2000001393-A2 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2000-01-13 | — | — | WO | claimed |
| CN-101601635-A | The prescription of little RNA/DNA whitening product and manufacture method | QINWEI YIN (CN) | 2009-12-16 | — | — | CN | disclosed |
| WO-2009011697-A1 | RNA OLIGONUCLEOTIDES TARGETING EBV AND HOST GENES AND THEIR USE FOR TREATMENT OF NASOPHARYNGEAL CARCINOMAS | OLIGOS ETC. INC. (US) | 2009-01-22 | — | — | WO | disclosed |
| US-7074769-B2 | Oligonucleotide inhibitors of bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2006-07-11 | — | — | US | disclosed |
| US-7074769-B2 | Oligonucleotide inhibitors of bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1093373-A4 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | UNIV COLUMBIA (US) | 2005-04-13 | — | — | EP | disclosed |
| CN-1506041-A | Formulation and making process of genetic skin beautifying and whitening cosmetics | 殷冬生 | 2004-06-23 | — | — | CN | disclosed |
| CN-1427008-A | Method of designing and selecting natural siRNA as gene medicine and medicine formulation | YIN DONGSHENG (CN) | 2003-07-02 | — | — | CN | disclosed |
| US-20030017196-A1 | Oligonucleotide inhibitors of bcl-xL | ARONEX PHARMACEUTICALS, INC. | 2003-01-23 | — | — | US | disclosed |
| US-20030017196-A1 | Oligonucleotide inhibitors of bcl-xL | ARONEX PHARMACEUTICALS, INC. | 2003-01-23 | — | — | US | disclosed |
| US-20020098231-A1 | Oligonucleotide inhibitors of bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2002-07-25 | — | — | US | disclosed |
| US-20020098231-A1 | Oligonucleotide inhibitors of bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2002-07-25 | — | — | US | disclosed |
| EP-1093373-A1 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-2000001393-A2 | OLIGONUCLEOTIDE INHIBITORS OF bcl-xL | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2000-01-13 | — | — | WO | disclosed |