SCHEMBL599432

SCHEMBL599432

Cc1ccnc(-c2c3nc(c(-c4cc(C)ccn4)c4ccc([nH]4)c(-c4cc(C)ccn4)c4nc(c(-c5cc(C)ccn5)c5ccc2[nH]5)C=C4)C=C3)c1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CCR1 P32246 1/20 0.50
▸ CCR5 P51681 1/20 0.50
▸ CCR8 P51685 1/20 0.50
▸ TERT O14746 5/20 0.43
▸ METAP2 P50579 1/20 0.41
▸ TOP1 P11387 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4359475 0.82 STAT3 (0.49) CCR1CCR5CCR8TERTMETAP2
SCHEMBL6394266 0.80 TERT (0.46) TERTTOP1
SCHEMBL6393380 0.78 TERT (0.44) TERTTOP1
SCHEMBL29822398 0.76 KDM4E (0.46) CCR1CCR5CCR8TERTMETAP2
SCHEMBL432185 0.76 KDM4E (0.46) CCR1CCR5CCR8TERTMETAP2
SCHEMBL6393600 0.76 TERT (0.42) TERTTOP1
SCHEMBL599851 0.75 KDM4E (0.45) CCR1CCR5CCR8TERTMETAP2
SCHEMBL9418754 0.75 KDM4E (0.45) CCR1CCR5CCR8TERTMETAP2
SCHEMBL29560659 0.75 KDM4E (0.45) CCR1CCR5CCR8TERTMETAP2
Magnesium SCHEMBL9418766 0.75 KDM4E (0.45) CCR1CCR5CCR8TERTMETAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2862936-B1 OXIDOREDUCTASE REACTION CONTROL USING AMINO SUBSTITUTED BIPYRIDINIUM COMPOUNDS AMANO ENZYME INC (JP) 2021-12-22 — — EP disclosed
US-9777299-B2 Oxidoreductase reaction control and use thereof AMANO ENZYME INC. (JP) 2017-10-03 — — US disclosed
EP-2862936-A1 OXIDOREDUCTASE REACTION CONTROL AND USE THEREOF Amano Enzyme Inc. (JP) 2015-04-22 — — EP disclosed
US-20130189347-A1 DISEASE TREATMENT DRUG YUASA MAKOTO (JP) 2013-07-25 — — US disclosed
EP-2601954-A1 THERAPEUTIC AGENT FOR DISEASE Yuasa, Makoto (JP) 2013-06-12 — — EP disclosed
US-20120039987-A1 NIOSOME HAVING METAL PORPHYRIN COMPLEX EMBEDDED THEREIN, PROCESS FOR PRODUCING THE SAME AND DRUG WITH THE USE THEREOF MAKOTO YUASA (JP) 2012-02-16 — — US disclosed
US-20080269184-A1 Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof YUASA, MAKOTO (JP) 2008-10-30 — — US disclosed
EP-1357946-B1 PHOTODYNAMIC THERAPY WITH REDUCED FLUENCE RATE QUADRA LOGIC TECH INC (CA) 2008-03-26 — — EP disclosed
EP-1731150-A1 NIOSOME HAVING METAL PORPHYRIN COMPLEX EMBEDDED THEREIN, PROCESS FOR PRODUCING THE SAME AND DRUG WITH THE USE THEREOF Yuasa, Makoto (JP) 2006-12-13 — — EP disclosed
US-20050008687-A1 Metal-porphyrin-complex-embedded liposomes, production process thereof, and medicines making use of the same MAKOTO YUASA (JP) 2005-01-13 — — US disclosed
US-20040266748-A1 Photosensitizing carbamate derivatives MIRAVANT PHARMACEUTICALS, INC. 2004-12-30 — — US disclosed
US-20040072769-A1 Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs YIN JAMES QINWEI (US) 2004-04-15 — — US disclosed
US-6372727-B1 ADMINISTERING IRON PORPHYRIN TO TREAT AMYOTROPHIC LATERAL SCLEROSIS; TREATING OXIDATIVE INJURY RELATED TO PEROXYNITRITE UAB RESEARCH FOUNDATION 2002-04-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130189347-A1 DISEASE TREATMENT DRUG PPOX, TFRC, SLC40A1 CCR1 3978/4885CCR5 4591/4885CCR8 4305/4885
US-20120039987-A1 NIOSOME HAVING METAL PORPHYRIN COMPLEX EMBEDDED THEREIN, PROCESS FOR PRODUCING THE SAME AND DRUG WITH THE USE THEREOF SOD1, SOD3, GPX1 CCR1 4311/4885CCR5 4176/4885CCR8 3644/4885
US-20040266748-A1 Photosensitizing carbamate derivatives CRY1, CASP3, CRY2 CCR1 4638/4885CCR5 4741/4885CCR8 4495/4885
US-20080269184-A1 Niosome Having Metal Porphyrin Complex Embedded Therein, Process For Producing The Same And Drug With The Use Thereof SOD1, SOD3, GPX1 CCR1 4328/4885CCR5 4223/4885CCR8 3675/4885
US-20050008687-A1 Metal-porphyrin-complex-embedded liposomes, production process thereof, and medicines making use of the same GPX4, FECH, PPOX CCR1 4849/4885CCR5 4454/4885CCR8 4851/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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