Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | PRKX | P51817 | 3/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.51 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359037 | 0.94 | ROCK2 (0.56) | ROCK2ROCK1MAPK1PRKACAPRKX | |
| SCHEMBL4356211 | 0.87 | MME (0.58) | CYP3A4GPR142PSMB5ALDH1A1MME | |
| SCHEMBL4363988 | 0.83 | TSHR (0.58) | CYP3A4GPR142PSMB5ALDH1A1 | |
| SCHEMBL4359110 | 0.83 | TSHR (0.58) | CYP3A4GPR142PSMB5ALDH1A1 | |
| SCHEMBL4367262 | 0.78 | ROCK2 (0.70) | ROCK2ROCK1MAPK1PRKACAPRKX | |
| SCHEMBL4364556 | 0.78 | CTSL (0.63) | ROCK2ROCK1MAPK1PRKACAPRKX | |
| SCHEMBL4364469 | 0.77 | ATM (0.60) | CYP3A4GPR142PSMB5ALDH1A1MMP9 | |
| SCHEMBL29788288 | 0.76 | ALDH1A1 (0.57) | CYP3A4GPR142PSMB5ALDH1A1MME | |
| SCHEMBL4367288 | 0.76 | CTSL (0.58) | ROCK2ROCK1MAPK1PRKACAPRKX | |
| SCHEMBL6487403 | 0.76 | CNR1 (0.56) | MAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247470-A1 | PHENYLALANINE DIPEPTIDE DERIVATIVES, COMPOSITIONS AND USE THEREOF | The Key Lab. Of Chemistry for Natural Products of Guizhou Province and Chinese Acad. of Sciences (CN) | 2009-10-01 | — | — | US | claimed |
| US-9023809-B2 | Phenylalanine dipeptide derivatives, compositions and use thereof | THE KEY LABORATORY OF CHEMISTRY FOR NATURAL PRODUCTS OF GUIZHOU PROVINCE AND CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-05 | — | — | US | disclosed |
| US-20090247470-A1 | PHENYLALANINE DIPEPTIDE DERIVATIVES, COMPOSITIONS AND USE THEREOF | The Key Lab. Of Chemistry for Natural Products of Guizhou Province and Chinese Acad. of Sciences (CN) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247470-A1 | PHENYLALANINE DIPEPTIDE DERIVATIVES, COMPOSITIONS AND USE THEREOF | DNPEP, PEPD, VIP | ROCK2 4037/4885ROCK1 2859/4885MAPK1 2260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.