SCHEMBL4360136

SCHEMBL4360136

CCC(C)OC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(=O)OC

nearest known ligand 0.62

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 3/20 0.62
GRM3 Q14832 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL230228 0.92 GRM2 (0.61) GRM2GRM3
SCHEMBL14932135 0.92 GRM2 (0.61) GRM2GRM3
SCHEMBL232547 0.92 GRM2 (0.75) GRM2GRM3
SCHEMBL1226471 0.92 GRM2 (0.75) GRM2GRM3
SCHEMBL11886412 0.86 GRM2 (0.83) GRM2GRM3
SCHEMBL232371 0.86 GRM2 (0.83) GRM2GRM3
Hydrochloric Acid SCHEMBL232370 0.86 GRM2 (0.81) GRM2GRM3
SCHEMBL4360133 0.84 GRM2 (0.62) GRM2GRM3
SCHEMBL2005245 0.83 GRM2 (0.69) GRM2GRM3
SCHEMBL514523 0.83 GRM2 (0.70) GRM2GRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2123630-A1 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative Taisho Pharmaceutical Co. Ltd. (JP) 2009-11-25 EP disclosed