Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.36 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368360 | 0.87 | EGLN3 (0.41) | EGLN1EGLN3HIF1AEGLN2 | |
| SCHEMBL3846999 | 0.87 | EGLN1 (0.44) | EGLN1EGLN3L3MBTL1FEN1EGLN2 | |
| SCHEMBL4367648 | 0.85 | EGLN1 (0.44) | EGLN1EGLN3HIF1AKDM4EEGLN2 | |
| SCHEMBL3851789 | 0.84 | EGLN1 (0.42) | EGLN1EGLN3L3MBTL1FEN1HIF1A | |
| SCHEMBL4359368 | 0.83 | EGLN3 (0.43) | EGLN1EGLN3HIF1AEGLN2 | |
| SCHEMBL4363082 | 0.81 | EGLN3 (0.51) | EGLN1EGLN3L3MBTL1EGLN2HTT | |
| SCHEMBL4356985 | 0.81 | EGLN3 (0.43) | EGLN1EGLN3HIF1AKDM4EEGLN2 | |
| SCHEMBL4364331 | 0.80 | HIF1A (0.43) | EGLN1EGLN3HIF1AALDH1A1TSHR | |
| SCHEMBL4359258 | 0.79 | EGLN3 (0.47) | EGLN1EGLN3EGLN2 | |
| SCHEMBL4362443 | 0.77 | EGLN3 (0.52) | EGLN1EGLN3EGLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |