Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15676840 | 0.77 | NOS3 (0.42) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL14924247 | 0.76 | TRPA1 (0.40) | HSD17B10ALOX15ALDH1A1TRPA1TP53 | |
| SCHEMBL18024311 | 0.74 | KMT2A (0.39) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL24493116 | 0.74 | DYRK1A (0.43) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL16306935 | 0.74 | NOS3 (0.39) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL1133886 | 0.74 | KDM4E (0.48) | ALOX15NOS3NOS2NOS1IDO1 | |
| SCHEMBL8268452 | 0.71 | KDM4E (0.50) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL11428015 | 0.71 | TRPA1 (0.59) | HSD17B10ALOX15ALDH1A1TRPA1TP53 | |
| SCHEMBL12490196 | 0.68 | KDM4E (0.44) | HSD17B10ALOX15ALDH1A1NOS3NOS2 | |
| SCHEMBL12490217 | 0.68 | NOS3 (0.41) | HSD17B10ALOX15ALDH1A1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618985-B2 | Isoquinoline derivatives | N.V. ORGANON (NL) | 2009-11-17 | — | — | US | disclosed |
| US-20070135479-A1 | Isoquinoline derivatives | N.V. ORGANON (NL) | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135479-A1 | Isoquinoline derivatives | ROCK1, ROCK2, RHOA | HSD17B10 757/4885ALOX15 2077/4885ALDH1A1 2436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.