Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362931 | 0.87 | KDM4E (0.46) | ALDH1A1KDM4ELMNAHTTRECQL | |
| SCHEMBL3850324 | 0.83 | KDM4E (0.44) | ALDH1A1KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL3857672 | 0.83 | KDM4E (0.47) | ALDH1A1KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL4368342 | 0.82 | AKR1B1 (0.55) | ALDH1A1KDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL4357096 | 0.82 | CYP19A1 (0.49) | ALDH1A1KDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4367648 | 0.81 | EGLN1 (0.44) | KDM4EHTTMEN1KMT2ATSHR | |
| SCHEMBL4360629 | 0.77 | AKR1B1 (0.40) | ALDH1A1KDM4EMAPTPKMMEN1 | |
| SCHEMBL4360566 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL3849089 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KDM4ELMNAMAPK1GAA | |
| SCHEMBL3852981 | 0.72 | KDM4E (0.48) | ALDH1A1KDM4ELMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |