Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850063 | 0.84 | CYP19A1 (0.49) | CYP19A1SMN1; SMN2ALDH1A1PTGDR2KMT2A | |
| SCHEMBL4368342 | 0.82 | AKR1B1 (0.55) | SMN1; SMN2ALDH1A1KMT2AMEN1PTGES | |
| SCHEMBL4364951 | 0.82 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4361363 | 0.82 | PTGDR2 (0.48) | PTGDR2KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL4362931 | 0.77 | KDM4E (0.46) | ALDH1A1PTGDR2KMT2AMEN1LMNA | |
| SCHEMBL3848644 | 0.75 | MAPK1 (0.67) | CYP19A1SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL4360629 | 0.73 | AKR1B1 (0.40) | ALDH1A1PTGDR2KMT2AMEN1ALOX5 | |
| SCHEMBL4360566 | 0.73 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL29699784 | 0.73 | CYP19A1 (0.57) | CYP19A1SMN1; SMN2PTGDR2KMT2AMEN1 | |
| SCHEMBL15498678 | 0.72 | CYP19A1 (0.56) | CYP19A1SMN1; SMN2ALDH1A1PTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |