Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360629 | 0.87 | AKR1B1 (0.40) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3849074 | 0.85 | AKR1B1 (0.50) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4357096 | 0.82 | CYP19A1 (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2ALOX5 | |
| SCHEMBL4373002 | 0.82 | AKR1B1 (0.55) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4364951 | 0.82 | ALDH1A1 (0.45) | MEN1KMT2AHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL4362931 | 0.77 | KDM4E (0.46) | MEN1CYP1A2CYP2C9KMT2AHSD17B10 | |
| SCHEMBL11162987 | 0.76 | AKR1B1 (0.74) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3851808 | 0.74 | ALDH1A1 (0.42) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL4360566 | 0.74 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11158759 | 0.74 | AKR1B1 (0.60) | AKR1B1MEN1CYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |