Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14881216 | 1.00 | CES1 (0.46) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL1659349 | 0.76 | MAPK1 (0.48) | CES1KCNN4ALDH1A1ALOX15MAPK1 | |
| SCHEMBL4368737 | 0.75 | MAPT (0.48) | KCNN4MAPTKMT2ACYP2C19HIF1A | |
| SCHEMBL2856854 | 0.75 | CES1 (0.42) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL18259095 | 0.74 | CES1 (0.52) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL5046100 | 0.74 | KCNN4 (0.50) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL2517938 | 0.74 | KCNN4 (0.50) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL3700347 | 0.74 | KCNN4 (0.50) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL22722985 | 0.74 | KCNN4 (0.50) | CES1KCNN4MAPTKMT2ACYP2C19 | |
| SCHEMBL8036600 | 0.74 | KCNN4 (0.50) | CES1KCNN4MAPTKMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | CIPLA LIMITED (IN) | 2014-09-11 | — | — | US | disclosed |
| EP-2768811-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST | Cipla Limited (IN) | 2014-08-27 | — | — | EP | disclosed |
| WO-2013057468-A1 | PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST | CIPLA LIMITED (IN) | 2013-04-25 | — | — | WO | disclosed |
| US-7582647-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2009-09-01 | — | — | US | disclosed |
| US-20070203338-A1 | Novel carboxylic acid derivatives, their preparation and use | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203338-A1 | Novel carboxylic acid derivatives, their preparation and use | HCAR1, HCAR2, HCAR3 | CES1 162/4885KCNN4 4213/4885MAPT 3324/4885 |
| US-20140256004-A1 | Process for the Preparation of an Endothelin Receptor Antagonist | EDNRB, EDNRA, AGTR1 | CES1 2317/4885KCNN4 1567/4885MAPT 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.