Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046716 | 0.88 | DHODH (0.58) | DHODHKDM4EGAATDP1RAB9A | |
| SCHEMBL395325 | 0.88 | DHODH (0.46) | DHODHTP53KDM4EGAATDP1 | |
| SCHEMBL3883132 | 0.87 | DHODH (0.44) | DHODHTP53KDM4ERAB9AFPR2 | |
| SCHEMBL846105 | 0.87 | MAPT (0.45) | DHODHKDM4EGAATDP1NPSR1 | |
| SCHEMBL62489 | 0.86 | NPC1 (0.46) | DHODHTDP1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL3852129 | 0.86 | ALDH1A1 (0.45) | DHODHKDM4EGAARAB9ANPSR1 | |
| SCHEMBL3785519 | 0.84 | PLK1 (0.42) | DHODHRAB9ANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7066341 | 0.83 | KDM4E (0.44) | DHODHKDM4EGAAALDH1A1MAPT | |
| SCHEMBL5295057 | 0.81 | GAA (0.47) | DHODHTP53KDM4EGAARAB9A | |
| SCHEMBL3370547 | 0.81 | MAPT (0.45) | DHODHKDM4EGAATDP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220047-B1 | Quinoline derivatives, pharmaceutical compositions comprising them, and use thereof | CLANOTECH AB (SE) | 2015-05-06 | — | — | EP | disclosed |
| US-8957092-B2 | Quinoline derivatives and their use as tyrosine kinase inhibitors | CLANOTECH AB (SE) | 2015-02-17 | — | — | US | disclosed |
| US-20140018388-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | CLANO TECH AB (SE) | 2014-01-16 | — | — | US | disclosed |
| US-8557843-B2 | Quinoline derivatives and their use as tyrosine kinase inhibitors | CLANOTECH AB (SE) | 2013-10-15 | — | — | US | disclosed |
| EP-2432764-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | ClanoTech AB (SE) | 2012-03-28 | — | — | EP | disclosed |
| US-20120065199-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | CLANOTECH AB (SE) | 2012-03-15 | — | — | US | disclosed |
| US-20110053976-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2011-03-03 | — | — | US | disclosed |
| WO-2010133669-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | CLANOTECH AB (SE) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010133672-A1 | DERIVATIVES OF QUINOLINE-3-CARBOXYLIC ACID AND THEIR MEDICAL USE | CLANOTECH AB (SE) | 2010-11-25 | — | — | WO | disclosed |
| EP-2220047-A2 | COMPOUNDS AND METHODS | ClanoTech AB (SE) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009063070-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2009-05-22 | — | — | WO | disclosed |
| WO-2008119771-A2 | QUINOLINE-S-CARBOXYLIC ACID DERIVATIVES AS TYROSINE KINASE INHIBITORS | CLANOTECH AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| US-20060063805-A1 | Thiazolinone 4-monosubstituted quinolines | CHEN LI | 2006-03-23 | — | — | US | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053976-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BRAF, MAP3K1, MAP3K7 | DHODH 1228/4885TP53 242/4885KDM4E 2483/4885 |
| US-20140018388-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BRAF, TYK2, MAP3K6 | DHODH 853/4885TP53 252/4885KDM4E 1262/4885 |
| US-20060063805-A1 | Thiazolinone 4-monosubstituted quinolines | CDK1, CDK14, CDK17 | DHODH 1095/4885TP53 94/4885KDM4E 1106/4885 |
| US-20120065199-A1 | SUBSTITUTED QUINOLINES FOR USE AS VEGF INHIBITORS | FLT1, FLT4, VEGFA | DHODH 1007/4885TP53 58/4885KDM4E 3451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.