SCHEMBL4366414

SCHEMBL4366414

ClC(Cl)=C(c1ccccc1)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.57
MAPK1 P28482 2/20 0.57
CYP3A4 P08684 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
ATM Q13315 1/20 0.57
CES2 O00748 3/20 0.43
CES1 P23141 3/20 0.43
ALDH1A1 P00352 2/20 0.43
DAO P14920 1/20 0.43
NAPRT Q6XQN6 1/20 0.43
ESR1 P03372 1/20 0.41
TRPA1 O75762 1/20 0.40
GSK3B P49841 1/20 0.40
HIF1A Q16665 1/20 0.40
F2 P00734 1/20 0.39
F10 P00742 1/20 0.39
F12 P00748 1/20 0.39
F7 P08709 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28930655 0.97 TSHR (0.55) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL7772998 0.87 TSHR (0.81) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL10672694 0.87 MEN1 (0.81) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL27991299 0.81 CES2 (0.43) TSHRMAPK1CYP3A4L3MBTL1CES2
SCHEMBL13586722 0.80 TSHR (0.50) TSHRMAPK1CYP3A4L3MBTL1MEN1
Benzene SCHEMBL28326432 0.79 CES1 (0.53) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL67982 0.79 CES1 (0.53) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL18294893 0.79 ESR1 (0.50) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL13586719 0.77 AKT1 (0.70) TSHRMAPK1CYP3A4L3MBTL1MEN1
SCHEMBL2270825 0.77 CES2 (0.39) TSHRMAPK1CYP3A4L3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114410260-A Modified epoxy resin adhesive and preparation method thereof 中国航空制造技术研究院 2022-04-29 CN claimed
CN-109265311-B Phenyl fluorene derivative and preparation method and application thereof 上海兆维科技发展有限公司 2021-06-04 CN claimed
CN-111540506-B High-wear-resistance umbilical cable for ocean research 江苏江扬特种电缆有限公司 2021-01-15 CN claimed
CN-111540506-A High-wear-resistance umbilical cable for ocean research 江苏江扬特种电缆有限公司 2020-08-14 CN claimed
CN-120160227-A Indoor air cleaning system 研能科技股份有限公司 2025-06-17 CN disclosed
CN-119517429-A Multidimensional data fusion processing method for medical text data 重庆邮电大学 2025-02-25 CN disclosed
CN-118984866-A Agave spirit replica 艾娃食品实验室股份有限公司 2024-11-19 CN disclosed
CN-118871560-A Rum replica 艾娃食品实验室股份有限公司 2024-10-29 CN disclosed
CN-118339274-A Brandy replica 艾娃食品实验室股份有限公司 2024-07-12 CN disclosed
CN-112204012-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-12-26 CN disclosed
CN-112204006-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-11-28 CN disclosed
CN-112154142-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-11-21 CN disclosed
US-7625988-B2 Maintain flexibility WILLIAM MARSH RICE UNIVERSITY (US) 2009-12-01 US disclosed
US-20060178462-A1 Flame retardant polymers WILLIAM MARSH RICE UNIVERSITY (US) 2006-08-10 US disclosed
WO-2004113265-A1 FLAME RETARDANT POLYMERS WILLIAM MARSH RICE UNIVERSITY (US) 2004-12-29 WO disclosed
EP-0519807-B1 Process for the dehydrochlorination of 1,1-bis(R-phényl)-2,2,2-trichloroethanes ATOCHEM ELF SA (FR) 1995-08-09 EP disclosed
US-5243110-A DEHYDROCHLORINATION OF 1,1-BIS(R-PHENYL)-2,2,2-TRICHLOROETHANES ELF ATOCHEM S.A. (FR) 1993-09-07 US disclosed
EP-0519807-A1 Process for the dehydrochlorination of 1,1-bis(R-phényl)-2,2,2-trichloroethanes ELF ATOCHEM S.A. (FR) 1992-12-23 EP disclosed
US-4156099-A TRIFLUOROMETHANESULFONIC ACID CATALYST GENERAL ELECTRIC COMPANY (US) 1979-05-22 US disclosed
US-4107442-A Process for preparing dihydroxydiphenyl chloroethylenes GENERAL ELECTRIC COMPANY (US) 1978-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060178462-A1 Flame retardant polymers PFAS, PCBP1, AFF4 TSHR 1618/4885MAPK1 3943/4885CYP3A4 1263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.