Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4040175 | 0.82 | KMT2A (0.50) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL4039125 | 0.82 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL1577410 | 0.80 | MEN1 (0.48) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4044757 | 0.80 | MEN1 (0.48) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4034697 | 0.80 | MEN1 (0.48) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4043637 | 0.79 | RAB9A (0.41) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4035037 | 0.79 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL4040874 | 0.78 | PTPN1 (0.44) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4044363 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL4043980 | 0.77 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038259-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F.HOFFMANN-LA ROCHE AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008000643-A1 | BENZIMIDAZOLE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS FXR AGONISTS AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-03 | — | — | WO | disclosed |