Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366799 | 0.78 | MAPKAPK2 (0.42) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL4366803 | 0.77 | NPC1 (0.36) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL12784950 | 0.65 | MAPKAPK2 (0.45) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL6990875 | 0.62 | PLK1 (0.36) | MAPKAPK2KMT2AGSK3AGSK3BPLK1 | |
| SCHEMBL1368536 | 0.61 | JAK2 (0.58) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL1368538 | 0.61 | JAK2 (0.58) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL6419841 | 0.61 | SLC6A3 (0.53) | NPC1MAPTRAB9AKMT2AGRM5 | |
| SCHEMBL6987283 | 0.61 | KMT2A (0.44) | MAPKAPK2TSHRALOX15CASP1NPSR1 | |
| SCHEMBL6987810 | 0.61 | ABCC9 (0.47) | NPC1RAB9AMAPKAPK2KMT2AGSK3A | |
| SCHEMBL6985552 | 0.60 | GAA (0.35) | NPC1RAB9ASMN1; SMN2MAPKAPK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |