Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6988688 | 0.83 | ABCC9 (0.41) | NPC1RAB9ATSHRMAPKAPK2 | |
| SCHEMBL6990616 | 0.83 | KMT2A (0.50) | NPC1MAPTRAB9ASMN1; SMN2TSHR | |
| SCHEMBL6988211 | 0.78 | POLB (0.40) | NPC1MAPTRAB9ANPSR1KMT2A | |
| SCHEMBL4366799 | 0.77 | MAPKAPK2 (0.42) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL4366779 | 0.77 | NPC1 (0.37) | NPC1TP53MAPTNFKB1RAB9A | |
| SCHEMBL6991619 | 0.76 | TYK2 (0.37) | MAPT | |
| SCHEMBL6990458 | 0.71 | CSF1R (0.44) | NPC1MAPTRAB9ATSHRMAPKAPK2 | |
| SCHEMBL6991687 | 0.71 | KMT2A (0.42) | NPC1RAB9ASMN1; SMN2TSHRKMT2A | |
| SCHEMBL6989487 | 0.70 | ALDH1A1 (0.49) | RAB9ASMN1; SMN2TSHRKMT2AKDM4E | |
| SCHEMBL6988180 | 0.69 | NAMPT (0.51) | NPC1MAPTRAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009012375-A2 | SQUARATE KINASE INHIBITORS | WYETH (US) | 2009-01-22 | — | — | WO | disclosed |
| EP-1358160-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002062761-A1 | AMINAL DIONES AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |