Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH5A1 | P51649 | 2/20 | 0.39 |
| ▸ | ABAT | P80404 | 2/20 | 0.39 |
| ▸ | AOX1 | Q06278 | 2/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14270671 | 0.85 | HPGD (0.43) | KDM4ECYP2A6ALDH1A1ALDH1A3HPGD | |
| SCHEMBL12216403 | 0.85 | HPGD (0.35) | KDM4ECYP2A6ALDH1A1HPGDAOX1 | |
| SCHEMBL14709469 | 0.84 | ALDH1A1 (0.43) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL7125837 | 0.83 | CYP2A6 (0.44) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL2601956 | 0.81 | KDM4E (0.46) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL26048868 | 0.80 | TDP1 (0.41) | PTGS2ALDH1A1HPGDTDP1SHBG | |
| SCHEMBL13644404 | 0.80 | ALDH1A1 (0.43) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL15659545 | 0.80 | CYP2A6 (0.41) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL13644405 | 0.80 | ALDH1A1 (0.43) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 | |
| SCHEMBL16322814 | 0.79 | SRC (0.51) | KDM4EPTGS2RAB9ACYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230250097-A1 | BENZO[C][2,6]NAPHTHYRIDINE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USES THEREOF | Apollo Therapeutics Limited (GB) | 2023-08-10 | — | — | US | disclosed |
| US-9562025-B2 | Compounds with (1E, 6E)-1,7-Bis-(3,4-dimethoxyphenyl)-4-4-distributed-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | ALLIANZ PHARMASCIENCE LTD. (TW) | 2017-02-07 | — | — | US | disclosed |
| US-20160264539-A1 | COMPOUNDS WITH (1E, 6E)-1,7-BIS-(3,4-DIMETHOXYPHENYL)-4-4-DISUBSTITUTED-HEPTA-1,6-DIENE-3,5-DIONE STRUCTURAL SCAFFOLD, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | Annji Pharmaceutical Co., Ltd. (TW) | 2016-09-15 | — | — | US | disclosed |
| US-20150190351-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | Annji Pharmaceutical Co., Ltd. (TW) | 2015-07-09 | — | — | US | disclosed |
| US-9000222-B2 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | ANDROSCIENCE CORPORATION (US) | 2015-04-07 | — | — | US | disclosed |
| US-8575221-B2 | Derivatives of dimethylcurcumin | CONCERT PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120107886-A1 | Lignin Oxidation and Products Thereof | STRATEGIC ENZYME APPLICATIONS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20110257271-A1 | DERIVATIVES OF DIMETHYLCURCUMIN | CONCERT PHARMACEUTICALS, INC. | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257271-A1 | DERIVATIVES OF DIMETHYLCURCUMIN | UROD, UGT1A1, UGT1A3 | KDM4E 1634/4885PTGS2 1534/4885RAB9A 3095/4885 |
| US-20230250097-A1 | BENZO[C][2,6]NAPHTHYRIDINE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USES THEREOF | CSNK1A1, CSNK1D, CSNK2A1 | KDM4E 1845/4885PTGS2 2092/4885RAB9A 2946/4885 |
| US-20120107886-A1 | Lignin Oxidation and Products Thereof | LOX, LPO, NOX4 | KDM4E 512/4885PTGS2 1343/4885RAB9A 4258/4885 |
| US-20150190351-A1 | Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof | AR, BRCA1, CYP17A1 | KDM4E 1922/4885PTGS2 1314/4885RAB9A 1893/4885 |
| US-20160264539-A1 | COMPOUNDS WITH (1E, 6E)-1,7-BIS-(3,4-DIMETHOXYPHENYL)-4-4-DISUBSTITUTED-HEPTA-1,6-DIENE-3,5-DIONE STRUCTURAL SCAFFOLD, THEIR BIOLOGICAL ACTIVITY, AND USES THEREOF | AR, CYP17A1, SRD5A1 | KDM4E 848/4885PTGS2 1169/4885RAB9A 3037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.