Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.52 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.52 |
| ▸ | FADS1 | O60427 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592431 | 0.82 | RIPK2 (0.62) | ABCG2ABCB1KDRPOLBKMT2A | |
| SCHEMBL12180640 | 0.80 | RIPK2 (0.52) | ABCG2ABCB1KDRPOLBKMT2A | |
| SCHEMBL15094547 | 0.79 | KMT2A (0.62) | ABCG2DNMT1DNMT3AFADS1EGFR | |
| SCHEMBL669669 | 0.78 | MAPT (0.80) | DNMT1DNMT3AHDAC3ACHEHDAC1 | |
| SCHEMBL8374513 | 0.75 | MAPK1 (0.60) | ABCG2ABCB1EGFRKMT2AKDM4E | |
| SCHEMBL15879950 | 0.74 | ERBB2 (0.66) | ABCG2DNMT1DNMT3AFADS1EGFR | |
| SCHEMBL5211538 | 0.74 | ABCG2 (0.58) | ABCG2ABCB1EGFRKMT2AALDH1A1 | |
| SCHEMBL670281 | 0.74 | USP2 (0.65) | DNMT1DNMT3AHDAC3ACHEHDAC1 | |
| SCHEMBL4882303 | 0.73 | EGFR (0.69) | DNMT1DNMT3AFADS1EGFRHDAC3 | |
| SCHEMBL4373769 | 0.73 | ABCG2 (0.49) | ABCG2ABCB1KDRPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531553-B2 | Heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1638954-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC. (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20040209892-A1 | Heterocyclic compounds and methods of use | U.S. PATENT OPERATIONS | 2004-10-21 | — | — | US | disclosed |
| WO-2004085425-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC (US) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040209892-A1 | Heterocyclic compounds and methods of use | VHL, NQO1, HPGDS | ABCG2 91/4885ABCB1 282/4885DNMT1 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.