Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrous Acid SCHEMBL5769883 | 0.91 | PKM (0.49) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL11592021 | 0.88 | ALDH1A1 (0.54) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL11592455 | 0.87 | ALDH1A1 (0.53) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL3144323 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL29847477 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL16923006 | 0.84 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL11591569 | 0.84 | ALDH1A1 (0.49) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL20854567 | 0.82 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL7336644 | 0.82 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL2341345 | 0.82 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498338-B2 | Compounds | ASTRAZENECA AB (SE) | 2009-03-03 | — | — | US | disclosed |
| US-20070129393-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2007-06-07 | — | — | US | disclosed |
| EP-1687311-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049620-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129393-A1 | Novel compounds | C1R, CHRM1, CHRM2 | ALDH1A1 2759/4885TP53 2175/4885TSHR 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.