Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20854567 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL2341345 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL9803136 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL7279015 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL9839070 | 0.86 | ALDH1A1 (0.47) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL22362311 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL21882038 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL21819606 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL22362302 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 | |
| SCHEMBL21050147 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TP53TSHRHIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3692018-A1 | MODULATORS OF CELL ADHESION, METHODS AND COMPOSITIONS THEREFOR | Blaschuk, Orest (US) | 2020-08-12 | — | — | EP | disclosed |
| US-10647672-B2 | Modulators of cell adhesion, methods and compositions therefor | Zonula, Inc. (CA) | 2020-05-12 | — | — | US | disclosed |
| US-10647672-B2 | Modulators of cell adhesion, methods and compositions therefor | Zonula, Inc. (CA) | 2020-05-12 | — | — | US | disclosed |
| US-20200048200-A1 | Modulators of cell adhesion, methods and compositions therefor | BLASCHUK, OREST, DR. (CA) | 2020-02-13 | — | — | US | disclosed |
| US-20200048200-A1 | Modulators of cell adhesion, methods and compositions therefor | BLASCHUK, OREST, DR. (CA) | 2020-02-13 | — | — | US | disclosed |
| WO-2019070816-A1 | MODULATORS OF CELL ADHESION, METHODS AND COMPOSITIONS THEREFOR | Zonula Incorporated (CA) | 2019-04-11 | — | — | WO | disclosed |
| US-20190100493-A1 | Modulators of cell adhesion, methods and compositions therefor | BLASCHUK, OREST, DR. (CA) | 2019-04-04 | — | — | US | disclosed |
| US-20190100493-A1 | Modulators of cell adhesion, methods and compositions therefor | BLASCHUK, OREST, DR. (CA) | 2019-04-04 | — | — | US | disclosed |
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100493-A1 | Modulators of cell adhesion, methods and compositions therefor | CDH1, EPCAM, ICAM1 | ALDH1A1 707/4885TP53 376/4885TSHR 4880/4885 |
| US-10647672-B2 | Modulators of cell adhesion, methods and compositions therefor | CDH1, EPCAM, ICAM1 | ALDH1A1 707/4885TP53 376/4885TSHR 4880/4885 |
| US-20200048200-A1 | Modulators of cell adhesion, methods and compositions therefor | CDH1, EPCAM, ICAM1 | ALDH1A1 707/4885TP53 376/4885TSHR 4880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.