Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 8/20 | 0.44 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230138 | 0.86 | UTS2R (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4228901 | 0.86 | HDAC1 (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4229796 | 0.86 | HDAC1 (0.53) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2383746 | 0.85 | HDAC1 (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2385454 | 0.80 | UTS2R (0.45) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2386741 | 0.80 | HDAC3 (0.43) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2385632 | 0.79 | UTS2R (0.43) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL4229534 | 0.79 | HDAC3 (0.46) | HDAC1HDAC3HDAC8HDAC2HDAC10 | |
| SCHEMBL2384677 | 0.79 | HDAC1 (0.49) | HDAC1HDAC3HDAC8HDAC2NCOR2 | |
| SCHEMBL4224435 | 0.77 | HDAC1 (0.47) | HDAC1HDAC3HDAC8HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |