Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225149 | 0.88 | HDAC1 (0.50) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL4368308 | 0.86 | HDAC1 (0.47) | HDAC1SMN1; SMN2HDAC3HDAC8MAPT | |
| SCHEMBL4365544 | 0.85 | HDAC1 (0.47) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL2473990 | 0.79 | HDAC1 (0.67) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL3218525 | 0.79 | SMN1; SMN2 (0.41) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL2474374 | 0.78 | HDAC1 (0.65) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL2477893 | 0.77 | HDAC1 (0.64) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL4219712 | 0.77 | UTS2R (0.39) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL4229101 | 0.77 | ALDH1A1 (0.39) | HDAC1RAB9ANPC1SMN1; SMN2PKM | |
| SCHEMBL4229785 | 0.76 | HDAC1 (0.47) | HDAC1RAB9ANPC1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |