Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546954 | 0.84 | HSD11B1 (0.41) | TAAR1TSHRGCGRMCL1 | |
| SCHEMBL6547350 | 0.83 | DHFR (0.47) | TAAR1GCGRMCL1 | |
| SCHEMBL6547458 | 0.80 | TAAR1 (0.44) | PDCD1CD274TAAR1FABP4TSHR | |
| SCHEMBL29493080 | 0.79 | TAAR1 (0.56) | TAAR1TSHRPOLBKDM4E | |
| SCHEMBL80017 | 0.79 | TAAR1 (0.56) | TAAR1TSHRPOLBKDM4E | |
| SCHEMBL1983595 | 0.79 | GABRA1 (0.44) | PDCD1CD274TSHRGCGRPOLB | |
| Water SCHEMBL29017465 | 0.77 | TAAR1 (0.54) | TAAR1TSHRPOLBKDM4E | |
| SCHEMBL8683332 | 0.76 | SLC6A2 (0.42) | PDCD1CD274TAAR1FABP4FFAR1 | |
| SCHEMBL79526 | 0.76 | ESR1 (0.43) | PDCD1CD274TAAR1PTGER1PTGER4 | |
| SCHEMBL3790918 | 0.76 | DPP4 (0.52) | PDCD1CD274TAAR1FABP4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7626055-B2 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-01 | — | — | US | disclosed |
| US-20070105850-A1 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105850-A1 | Biphenyl-carboxamide derivatives and their use as p38 kinase inhibitors | MAPK1, MAPKAPK2, MAP3K8 | PDCD1 1497/4885CD274 2971/4885TAAR1 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.