Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | SLC8A1 | P32418 | 17/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365891 | 0.89 | HSPB1 (0.47) | MAPTNPSR1HSPB1SLC8A1 | |
| SCHEMBL4369918 | 0.88 | HSPB1 (0.43) | MAPTNPSR1HSPB1SLC8A1 | |
| SCHEMBL4366186 | 0.87 | HSPB1 (0.43) | MAPTNPSR1HSPB1SLC8A1 | |
| SCHEMBL4364082 | 0.85 | HSPB1 (0.46) | MAPTNPSR1HSPB1SLC8A1 | |
| SCHEMBL4368867 | 0.85 | SLC8A1 (0.45) | SLC8A1 | |
| SCHEMBL4367679 | 0.85 | SLC8A1 (0.45) | SLC8A1 | |
| SCHEMBL4361661 | 0.85 | SLC8A1 (0.54) | SLC8A1 | |
| SCHEMBL30540995 | 0.85 | SLC8A1 (0.54) | SLC8A1 | |
| SCHEMBL4365826 | 0.84 | MAPT (0.56) | MAPTNPSR1HSPB1SLC8A1RAB9A | |
| SCHEMBL4954358 | 0.84 | MAPT (0.46) | MAPTNPSR1HSPB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482340-B2 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2009-01-27 | — | — | US | disclosed |
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | ORION CORPORATION (FI) | 2006-10-26 | — | — | US | disclosed |
| EP-1583759-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063191-A1 | PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM | ORION CORPORATION (FI) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241147-A1 | Pyridine derivatives useful for inhibiting sodium/calcium exchange system | SLC8B1, CACNA1A, MCU | MAPT 2223/4885NPSR1 945/4885HSPB1 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.