Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369086 | 1.00 | PARP1 (0.46) | PARP1MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1420391 | 0.82 | LMNA (0.37) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL1420388 | 0.82 | LMNA (0.37) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL6046306 | 0.80 | NFKB1 (0.56) | PARP1MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL1420660 | 0.80 | TRIM24 (0.58) | KMT2ADYRK1AGSK3BNFATC1SLC6A4 | |
| SCHEMBL6046307 | 0.80 | NFKB1 (0.56) | PARP1MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL2541206 | 0.78 | MAPT (0.48) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL3417896 | 0.78 | TDO2 (0.50) | PARP1MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL2541208 | 0.78 | MAPT (0.48) | MEN1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL3417898 | 0.78 | TDO2 (0.50) | PARP1MEN1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217028-B2 | 1,2,4-oxadiazole indole compounds | GLAXO GROUP LIMITED (GB) | 2012-07-10 | — | — | US | disclosed |
| WO-2009153307-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |