Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.54 |
| ▸ | PDE4A | P27815 | 3/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.54 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL1900204 | 0.93 | PDE4B (0.50) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL2078735 | 0.92 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| Pyrophosphoric Acid SCHEMBL3446718 | 0.84 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| Phosphoric Acid SCHEMBL4371348 | 0.78 | GPR84 (0.41) | PDE4BPDE4APDE4CPDE4DGPR84 | |
| Phosphoric Acid SCHEMBL5679958 | 0.78 | GPR84 (0.41) | PDE4BPDE4APDE4CPDE4DGPR84 | |
| Phosphoric Acid SCHEMBL28725997 | 0.75 | CAMK2A (0.42) | GPR84SRCTTR | |
| Phosphoric Acid SCHEMBL10438539 | 0.74 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| Pyrophosphoric Acid SCHEMBL10436218 | 0.73 | GPR84 (0.38) | PDE4BPDE4APDE4CPDE4DGPR84 | |
| SCHEMBL28036379 | 0.73 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DBACE1 | |
| SCHEMBL11210849 | 0.72 | BACE1 (0.48) | PDE4BPDE4APDE4CPDE4DBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109694568-A | A kind of High glow wire halogen-free flame retardant polyamide compound and the preparation method and application thereof | 广州市寅源新材料科技有限公司 | 2019-04-30 | — | — | CN | claimed |
| CN-109694568-A | A kind of High glow wire halogen-free flame retardant polyamide compound and the preparation method and application thereof | 广州市寅源新材料科技有限公司 | 2019-04-30 | — | — | CN | disclosed |
| CN-101932448-B | Polycarbonate resin layered sheet | TEIJIN CHEMICALS LTD | 2013-05-29 | — | — | CN | disclosed |
| CN-101932448-A | Polycarbonate resin layered sheet | TEIJIN CHEMICALS LTD | 2010-12-29 | — | — | CN | disclosed |
| US-7582693-B2 | Ann article with weld line strength using vibration or ultrasonic welding | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2009-09-01 | — | — | US | disclosed |
| EP-1622981-B1 | COMPOSITION AND METHOD FOR IMPROVING THE SURFACE ADHESION OF RESIN COMPOSITIONS TO POLYURETHANE FOAM | GEN ELECTRIC (US) | 2008-01-16 | — | — | EP | disclosed |
| US-7214739-B2 | Composition and method for improving the surface adhesion of resin compositions to polyurethane foam | GENERAL ELECTRIC COMPANY (US) | 2007-05-08 | — | — | US | disclosed |
| US-7015285-B2 | Composition and method for improving the adhesion of polyphenylene ether moldings to polyurethane foam | GENERAL ELECTRIC (US) | 2006-03-21 | — | — | US | disclosed |
| EP-1622981-A1 | COMPOSITION AND METHOD FOR IMPROVING THE SURFACE ADHESION OF RESIN COMPOSITIONS TO POLYURETHANE FOAM | GENERAL ELECTRIC COMPANY (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004094530-A1 | COMPOSITION AND METHOD FOR IMPROVING THE SURFACE ADHESION OF RESIN COMPOSITIONS TO POLYURETHANE FOAM | GENERAL ELECTRIC COMPANY (US) | 2004-11-04 | — | — | WO | disclosed |
| US-20040214960-A1 | Composition and method for enhancing the weld strength of polyphenylene ether compositions | GENERAL ELECTRIC COMPANY | 2004-10-28 | — | — | US | disclosed |
| US-20040214952-A1 | Composition and method for improving the surface adhesion of resin compositions to polyurethane foam | GENERAL ELECTRIC COMPANY | 2004-10-28 | — | — | US | disclosed |
| US-20040122159-A1 | Composition and method for improving the adhesion of polyphenylene ether moldings to polyurethane foam | GENERAL ELECTRIC COMPANY | 2004-06-24 | — | — | US | disclosed |
| EP-0849329-B1 | Composition and method for enhancing the surface adhesion of polyurethane foam to surfaces of thermoplastic blends | GEN ELECTRIC (US) | 2003-10-15 | — | — | EP | disclosed |
| US-6365665-B1 | FOR PRODUCING AUTOMOTIVE INSTRUMENT PANELS | GENERAL ELECTRIC COMPANY | 2002-04-02 | — | — | US | disclosed |
| US-6303216-B1 | BLENDING MIXTURE OF POLYPHENYLENE ETHER AND POLYALKENYLAROMATIC COMPOUND, ADDING PRIMARY OR SECONDARY AMINE COMPOUND AND FORMING SUBSTRATE; PLACING IN FOAMING MOLD SHELL; POURING FOAMING MIXTURE; REMOVING MOLD SHELL | GENERAL ELECTRIC COMPANY | 2001-10-16 | — | — | US | disclosed |
| US-6147161-A | COMPRISING A BLEND OF A POLYPHENYLENE ETHER AND AT LEAST ONE POLY(ALKENYLAROMATIC) SUCH AS POLYSTYRENE, AND AT LEAST ONE SPECIFIED PRIMARY OR SECONDARY AMINE-CONTAINING MATERIAL | GENERAL ELECTRIC COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0849329-A1 | Composition and method for enhancing the surface adhesion of polyurethane foam to surfaces of thermoplastic blends | GENERAL ELECTRIC COMPANY (US) | 1998-06-24 | — | — | EP | disclosed |
| US-5756196-A | BLEND OF POLYPHENYLENE ETHER, POLY(ALKENYLAROMATIC) COMPOUNDAND AMINE MODIFIED POLYETHER | GENERAL ELECTRIC COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| US-5413817-A | Method for adhering metal coatings to polyphenylene ether-polystyrene articles | GENERAL ELECTRIC COMPANY (US) | 1995-05-09 | — | — | US | disclosed |