SCHEMBL4369742

SCHEMBL4369742

CCOC(=O)OC1(Cc2ccccc2)CCN(C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)/C=C/CC(C)(C)N)CC1

nearest known ligand 0.51

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 8/20 0.48
OPRD1 P41143 1/20 0.36
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
DPP4 P27487 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4369760 0.91 GHSR (0.48) GHSRDPP4
SCHEMBL4382914 0.90 GHSR (0.50) GHSROPRD1DPP4
SCHEMBL4382952 0.89 OPRD1 (0.38) GHSROPRD1MEN1KMT2ADPP4
SCHEMBL7850052 0.89 GHSR (0.51) GHSRMEN1KMT2A
SCHEMBL866628 0.89 GHSR (0.51) GHSRMEN1KMT2A
SCHEMBL866629 0.89 GHSR (0.51) GHSRMEN1KMT2A
SCHEMBL866895 0.83 GHSR (0.53) GHSROPRD1DPP4
SCHEMBL866894 0.83 GHSR (0.53) GHSROPRD1DPP4
SCHEMBL4383130 0.83 GHSR (0.51) GHSROPRD1MEN1KMT2ADPP4
SCHEMBL867851 0.83 GHSR (0.51) GHSROPRD1MEN1KMT2ADPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077941-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2009-08-12 EP claimed