Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | NCF1 | P14598 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008328 | 0.84 | NPC1 (0.41) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL7144470 | 0.79 | KDM4E (0.37) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL28995850 | 0.76 | ADRA1A (0.49) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL29390450 | 0.69 | NPC1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL902873 | 0.69 | NPC1 (0.52) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL6729741 | 0.69 | NPC1 (0.39) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL7037068 | 0.68 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL4080687 | 0.68 | DDB1 (0.48) | NPC1RAB9AALDH1A1KMT2AMAPT | |
| SCHEMBL5106520 | 0.67 | NPC1 (0.42) | NPC1RAB9AALDH1A1CYP3A4MEN1 | |
| SCHEMBL3525605 | 0.66 | NPC1 (0.49) | NPC1RAB9AALDH1A1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036548-A1 | Prevention and treatment of inflammation-induced and/or immune-mediated bone loss | onepharm Research & Development GmbH (AT) | 2009-03-18 | — | — | EP | disclosed |