Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368106 | 0.93 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4371552 | 0.88 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4375642 | 0.88 | PSEN1 (0.38) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4367729 | 0.86 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4372515 | 0.85 | DGAT1 (0.56) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4374098 | 0.83 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4371954 | 0.83 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4382198 | 0.81 | DGAT1 (0.39) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4373446 | 0.80 | ALDH1A1 (0.42) | ALDH1A1GAAMAPTLMNAHTT | |
| SCHEMBL4372928 | 0.80 | FLT1 (0.43) | ALDH1A1GAAMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101300231-B | Pyridylsulfonamide derivatives, their manufacture and use as antineoplastic agents | HOFFMANN LA ROCHE | 2011-11-09 | — | — | CN | claimed |
| CN-101300231-A | Pyridylsulfonamide derivatives, their manufacture and use as antineoplastic agents | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | CN | claimed |
| US-20070123513-A1 | 6-thiomorpholin-4-yl-pyridine-3-sulfonic acid 4-chloro-2-methoxy-benzoylamide; ammonium salt of3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-sulfonic acid 4-chloro-2-methoxy-benzoylamide; anticarcinogenic agent | HOFFMANN-LA ROCHE INC. | 2007-05-31 | — | — | US | claimed |
| CN-101300231-B | Pyridylsulfonamide derivatives, their manufacture and use as antineoplastic agents | HOFFMANN LA ROCHE | 2011-11-09 | — | — | CN | disclosed |
| US-7625896-B2 | Pyridylsulfonamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-12-01 | — | — | US | disclosed |
| CN-101300231-A | Pyridylsulfonamide derivatives, their manufacture and use as antineoplastic agents | HOFFMANN LA ROCHE (CH) | 2008-11-05 | — | — | CN | disclosed |
| US-20070123513-A1 | 6-thiomorpholin-4-yl-pyridine-3-sulfonic acid 4-chloro-2-methoxy-benzoylamide; ammonium salt of3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-sulfonic acid 4-chloro-2-methoxy-benzoylamide; anticarcinogenic agent | HOFFMANN-LA ROCHE INC. | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123513-A1 | 6-thiomorpholin-4-yl-pyridine-3-sulfonic acid 4-chloro-2-methoxy-benzoylamide; ammonium salt of3-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-sulfonic acid 4-chloro-2-methoxy-benzoylamide; anticarcinogenic agent | TPMT, BPNT1, SLC6A3 | ALDH1A1 1180/4885GAA 3480/4885MAPT 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.