SCHEMBL4370987

SCHEMBL4370987

COC[C@@H]1C[C@@H](O)[C@H](n2cnc3c(=O)[nH]c(N)nc32)O1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HINT1 P49773 5/20 0.55
NT5E P21589 1/20 0.53
POLB P06746 1/20 0.52
TGM2 P21980 1/20 0.51
HPGD P15428 1/20 0.51
STING1 Q86WV6 2/20 0.50
GSK3A P49840 2/20 0.50
RPS6KA3 P51812 2/20 0.50
MAPK14 Q16539 2/20 0.50
PDE3B Q13370 1/20 0.50
PDE3A Q14432 1/20 0.50
FUT5 Q11128 1/20 0.50
PNP P00491 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL646778 0.91 HINT1 (0.54) HINT1NT5EPOLBTGM2STING1
SCHEMBL18520582 0.90 HINT1 (0.56) HINT1NT5EPOLBTGM2HPGD
SCHEMBL98907 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL98906 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL4323450 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL13833321 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL9200583 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL18759056 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL12031117 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD
SCHEMBL16695880 0.89 ADORA3 (0.53) HINT1NT5EPOLBTGM2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2010659-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA Epicentre Technologies (US) 2009-01-07 EP claimed
WO-2007120863-A2 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES (US) 2007-10-25 WO claimed
US-9115380-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2015-08-25 US disclosed
US-20150191760-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA CELLSCRIPT LLC (US) 2015-07-09 US disclosed
US-9005930-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2015-04-14 US disclosed
US-20140363876-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA EPICENTRE TECHNOLOGIES 2014-12-11 US disclosed
US-8846348-B2 Kits and methods for generating 5′ capped RNA CELLSCRIPT, LLC (US) 2014-09-30 US disclosed
US-20140221248-A1 KITS AND METHODS FOR GENERATING 5' CAPPED RNA CELLSCRIPT, LLC (US) 2014-08-07 US disclosed
EP-2010659-B1 Kits and methods for generating 5' capped RNA CELLSCRIPT INC (US) 2014-06-18 EP disclosed
US-20070281336-A1 Kits and methods for generating 5' capped RNA EPICENTRE TECHNOLOGIES (US) 2007-12-06 US disclosed