Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488303 | 0.83 | KDM1A (0.54) | MEN1HTTKMT2ADHFRNCF1 | |
| SCHEMBL27306674 | 0.83 | NCF1 (0.46) | DHFRNCF1SLC22A12LOXL2HTR1A | |
| SCHEMBL8560845 | 0.80 | NCF1 (0.42) | MEN1KMT2ANCF1SLC22A12SMN1; SMN2 | |
| SCHEMBL8563075 | 0.77 | MAPT (0.52) | MEN1HTTKMT2ADHFRSMN1; SMN2 | |
| SCHEMBL13239525 | 0.77 | HPGD (0.53) | MEN1HTTKMT2ASLC22A12SMN1; SMN2 | |
| SCHEMBL830704 | 0.74 | HTT (0.51) | MEN1HTTKMT2ADHFREGFR | |
| SCHEMBL29085862 | 0.74 | HDAC6 (0.52) | MEN1HTTKMT2ASMN1; SMN2LMNA | |
| SCHEMBL24871315 | 0.72 | SMN1; SMN2 (0.44) | MEN1HTTKMT2ADHFRSMN1; SMN2 | |
| SCHEMBL13730600 | 0.72 | SMN1; SMN2 (0.47) | MEN1HTTKMT2ADHFRSMN1; SMN2 | |
| SCHEMBL7488299 | 0.71 | NCF1 (0.56) | MEN1HTTKMT2ANCF1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061466-A2 | 4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS | Xtl Biopharmaceuticals Ltd. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008024423-A2 | 4-THIO SUBSTITUTED QUINOLINE AND NAPHTHYRIDINE COMPOUNDS | XTL BIOPHARMACEUTICALS LTD. (US) | 2008-02-28 | — | — | WO | disclosed |