Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27306674 | 0.77 | NCF1 (0.46) | MAPTDHFRRAB9A | |
| SCHEMBL4371190 | 0.77 | MEN1 (0.43) | LMNASMN1; SMN2DHFRMEN1KMT2A | |
| SCHEMBL7488303 | 0.77 | KDM1A (0.54) | MAPTLMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8564485 | 0.76 | LMNA (0.61) | MAPTLMNASMN1; SMN2ALDH1A1DHFR | |
| SCHEMBL2211171 | 0.75 | MAPT (0.47) | MAPTLMNASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL18788857 | 0.75 | ALDH1A1 (0.51) | MAPTLMNASMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL13239525 | 0.74 | HPGD (0.53) | MAPTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13265685 | 0.74 | MEN1 (0.63) | MAPTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL8560845 | 0.74 | NCF1 (0.42) | MAPTSMN1; SMN2ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL12410457 | 0.74 | POLB (0.44) | MAPTLMNASMN1; SMN2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |