Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29168216 | 0.81 | GRM4 (0.39) | NOS3NOS1NOS2MEN1KMT2A | |
| SCHEMBL15167171 | 0.79 | PLAU (0.46) | MEN1KMT2AHTTNPC1RAB9A | |
| SCHEMBL17696444 | 0.78 | NOS3 (0.52) | NOS3NOS1NOS2RAB9AGAA | |
| SCHEMBL1198968 | 0.78 | HTT (0.46) | MEN1KMT2AHTTHSD17B10NPC1 | |
| SCHEMBL31317020 | 0.78 | HTT (0.46) | MEN1KMT2AHTTHSD17B10NPC1 | |
| Hydrochloric Acid SCHEMBL21598444 | 0.78 | PLAU (0.44) | MEN1KMT2AHTTNPC1RAB9A | |
| Water SCHEMBL28877782 | 0.77 | HTT (0.45) | MEN1KMT2AHTTHSD17B10NPC1 | |
| Water SCHEMBL29974467 | 0.77 | HTT (0.45) | MEN1KMT2AHTTHSD17B10NPC1 | |
| SCHEMBL12411169 | 0.76 | PDE10A (0.43) | MEN1KMT2AHTTHSD17B10NPC1 | |
| SCHEMBL12037997 | 0.76 | PGK1 (0.42) | MEN1KMT2AHTTHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |