Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15283554 | 0.84 | CYP3A4 (0.31) | NT5E | |
| SCHEMBL15284060 | 0.79 | NT5E (0.38) | NT5ETRPV4MAT2ANOTUMKDM4E | |
| SCHEMBL23162813 | 0.79 | KDM4E (0.37) | NT5ETRPV4MAT2AKDM4EALDH1A1 | |
| SCHEMBL29760329 | 0.79 | KDM4E (0.37) | NT5ETRPV4MAT2AKDM4EALDH1A1 | |
| SCHEMBL2634744 | 0.79 | NOTUM (0.42) | NT5ETRPV4MAT2ANOTUMKDM4E | |
| SCHEMBL3153908 | 0.78 | TSHR (0.48) | — | |
| SCHEMBL537996 | 0.77 | P2RX7 (0.37) | NT5ETRPV4MAT2ANOTUMKDM4E | |
| SCHEMBL1451444 | 0.77 | NOTUM (0.41) | NT5ETRPV4MAT2ANOTUMKDM4E | |
| SCHEMBL16346468 | 0.77 | NT5E (0.41) | NT5ETRPV4MAT2AKDM4EALDH1A1 | |
| SCHEMBL2269503 | 0.77 | PTGS2 (0.37) | NT5ETRPV4KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831044-B1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2020-11-11 | — | — | EP | claimed |
| CN-104321310-B | Process for preparing 3-substituted-6-trifluoromethylpyridines and process for using 6-trichloromethyl halopyridines | 陶氏益农公司 | 2017-02-22 | — | — | CN | claimed |
| EP-2831044-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | Dow AgroSciences LLC (US) | 2015-02-04 | — | — | EP | claimed |
| CN-104321310-A | Process for preparing 3-substituted-6-trifluoromethylpyridines and process for using 6-trichloromethyl halopyridines | DOW AGROSCIENCES LLC | 2015-01-28 | — | — | CN | claimed |
| US-8785650-B2 | Methods for preparing 3-substituted-6-trifluoromethyl pyridines and methods for using 6-trichloromethyl halogenated pyridines | DOW AGROSCIENCES, LLC. (US) | 2014-07-22 | — | — | US | claimed |
| US-20130261310-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | CORTEVA AGRISCIENCE LLC | 2013-10-03 | — | — | US | claimed |
| WO-2013148338-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2013-10-03 | — | — | WO | claimed |
| JP-58206563-A | — | — | None | — | — | JP | disclosed |
| CN-107889486-B | Pyridin-2-ylpyridin/compounds and methods of use thereof | 日本曹达株式会社 | 2021-07-09 | — | — | CN | disclosed |
| EP-2831044-B1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2020-11-11 | — | — | EP | disclosed |
| EP-2831044-B1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2020-11-11 | — | — | EP | disclosed |
| US-10618882-B2 | Pyridine-2-yl pyridinium compound and method of using same | NIPPON SODA CO., LTD. (JP) | 2020-04-14 | — | — | US | disclosed |
| EP-3330253-B1 | PYRIDINE-2-YL-PYRIDINIUM COMPOUND AND METHOD OF USING SAME | NIPPON SODA CO (JP) | 2019-09-25 | — | — | EP | disclosed |
| US-20130261310-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | CORTEVA AGRISCIENCE LLC | 2013-10-03 | — | — | US | disclosed |
| US-20130261310-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | CORTEVA AGRISCIENCE LLC | 2013-10-03 | — | — | US | disclosed |
| WO-2013148338-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2013148338-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | DOW AGROSCIENCES LLC (US) | 2013-10-03 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| JP-S58206563-A | PREPARATION OF BETA-CHLORO-ALPHA- OR BETA-CHLORO-GAMMA- TRIFLUOROMETHYLPYRIDINE COMPOUND | ISHIHARA SANGYO KAISHA LTD | 1983-12-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261310-A1 | METHODS FOR PREPARING 3-SUBSTITUTED-6-TRIFLUOROMETHYL PYRIDINES AND METHODS FOR USING 6-TRICHLOROMETHYL HALOGENATED PYRIDINES | CYP4F3, CBR3, PRDX6 | NT5E 967/4885TRPV4 4466/4885MAT2A 2711/4885 |
| US-10618882-B2 | Pyridine-2-yl pyridinium compound and method of using same | PNPO, PDXK, ABCB7 | NT5E 2802/4885TRPV4 2108/4885MAT2A 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.