Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371328 | 0.89 | GAA (0.42) | GAASMN1; SMN2LMNAHPGDCNR1 | |
| SCHEMBL4371355 | 0.88 | CNR1 (0.49) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL4371339 | 0.81 | TP53 (0.43) | GAASMN1; SMN2LMNACNR1NPC1 | |
| SCHEMBL4375072 | 0.80 | CNR1 (0.49) | GAACNR1 | |
| SCHEMBL3922484 | 0.76 | CNR1 (0.53) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL3928208 | 0.76 | CNR1 (0.53) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL4370602 | 0.76 | HTR2C (0.38) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL3928212 | 0.74 | CNR1 (0.51) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL3918749 | 0.72 | CNR1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAHPGD | |
| SCHEMBL3921257 | 0.72 | CNR1 (0.52) | MEN1KMT2ASMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |