Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372553 | 0.86 | TP53 (0.47) | TP53RXFP1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4372095 | 0.81 | MEN1 (0.43) | TP53ALDH1A1GAALMNACNR1 | |
| SCHEMBL3916107 | 0.74 | ABL1 (0.47) | ALDH1A1ABL1CNR1CNR2NPC1 | |
| SCHEMBL3917692 | 0.73 | ABL1 (0.48) | ALDH1A1ABL1CNR1CNR2NPC1 | |
| SCHEMBL4379578 | 0.71 | ALDH1A1 (0.44) | KDM4EHSD17B10ALDH1A1GAACNR2 | |
| SCHEMBL4373432 | 0.71 | CNR1 (0.41) | RXFP1KDM4ECNR1CNR2TSHR | |
| SCHEMBL4370602 | 0.70 | HTR2C (0.38) | TP53HTR2CSLC6A4HSD17B10ALDH1A1 | |
| SCHEMBL4371328 | 0.70 | GAA (0.42) | KDM4EHSD17B10ALDH1A1GAALMNA | |
| SCHEMBL4380524 | 0.69 | EPHX1 (0.41) | RXFP1KDM4EHSD17B10ALDH1A1GLA | |
| SCHEMBL4373581 | 0.69 | EPHX1 (0.41) | RXFP1KDM4EHSD17B10ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-B1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | HOFFMANN LA ROCHE (CH) | 2009-05-27 | — | — | EP | claimed |