SCHEMBL4372111

SCHEMBL4372111

CNC(=O)C1(Cc2ccccc2)CCN(C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)C=C(C)CC(C)(C)N)CC1

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.42
OPRD1 P41143 1/20 0.38
DPP4 P27487 1/20 0.37
MC4R P32245 5/20 0.33
MC3R P41968 5/20 0.33
MC1R Q01726 5/20 0.33
CCKBR P32239 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL868448 1.00 GHSR (0.42) GHSROPRD1DPP4MC4RMC3R
SCHEMBL4372106 1.00 GHSR (0.42) GHSROPRD1DPP4MC4RMC3R
SCHEMBL868493 0.90 GHSR (0.37) GHSROPRD1DPP4CCKBR
SCHEMBL868492 0.90 GHSR (0.37) GHSROPRD1DPP4CCKBR
SCHEMBL7860577 0.89 MEN1 (0.43) GHSROPRD1
SCHEMBL868237 0.89 MEN1 (0.43) GHSROPRD1
SCHEMBL868238 0.89 MEN1 (0.43) GHSROPRD1
SCHEMBL4385374 0.88 GHSR (0.40) GHSROPRD1DPP4MC4RMC3R
SCHEMBL866895 0.88 GHSR (0.53) GHSROPRD1DPP4CCKBR
SCHEMBL866894 0.88 GHSR (0.53) GHSROPRD1DPP4CCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077941-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2009-08-12 EP disclosed