SCHEMBL4385374

SCHEMBL4385374

CNC(=O)OC1(Cc2ccccc2)CCN(C(=O)[C@@H](Cc2ccc3ccccc3c2)N(C)C(=O)/C=C(\C)CC(C)(C)N)CC1

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 7/20 0.40
OPRD1 P41143 1/20 0.35
DPP4 P27487 1/20 0.35
PPIA P62937 2/20 0.32
MC4R P32245 2/20 0.32
MC3R P41968 2/20 0.32
MC1R Q01726 2/20 0.32
CTSL P07711 2/20 0.32
CTSB P07858 2/20 0.32
CTSK P43235 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4382952 0.90 OPRD1 (0.38) GHSROPRD1DPP4
SCHEMBL4382914 0.89 GHSR (0.50) GHSROPRD1DPP4CTSLCTSB
SCHEMBL868448 0.88 GHSR (0.42) GHSROPRD1DPP4MC4RMC3R
SCHEMBL4372106 0.88 GHSR (0.42) GHSROPRD1DPP4MC4RMC3R
SCHEMBL4372111 0.88 GHSR (0.42) GHSROPRD1DPP4MC4RMC3R
SCHEMBL868238 0.84 MEN1 (0.43) GHSROPRD1
SCHEMBL7860577 0.84 MEN1 (0.43) GHSROPRD1
SCHEMBL868237 0.84 MEN1 (0.43) GHSROPRD1
SCHEMBL4375272 0.80 GHSR (0.35) GHSROPRD1DPP4
SCHEMBL13996829 0.79 GHSR (0.46) GHSROPRD1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1077941-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2009-08-12 EP claimed