Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL116215 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2593972 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11519286 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2411531 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1426398 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL633793 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7060057 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL11857836 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8400312 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4819877 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833922-B1 | A NOVEL METHOD TO ISOLATE MUTANTS AND TO CLONE THE COMPLEMENTING GENE | DANISCO (DK) | 2009-04-22 | — | — | EP | disclosed |
| EP-1514936-B1 | Nucleic acid sequence xlnR of the regulator of the xylanolytic pathway XylR from Aspergillus niger | DANISCO (DK) | 2007-12-05 | — | — | EP | disclosed |
| EP-1514936-A2 | A novel method to isolate mutants and to clone the complementing gene | DANISCO A/S (DK) | 2005-03-16 | — | — | EP | disclosed |
| US-6599745-B1 | Generation of mutant microorganism; obtain cells, transform with vector, culture, recover transformed cells, incubate with mutagen, monitor phenotype, recover cells of preferential phenotype | DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) | 2003-07-29 | — | — | US | disclosed |
| EP-0463706-B1 | Cloning and expression of xylanase genes from fungal origin | DSM NV (NL) | 2003-03-05 | — | — | EP | disclosed |
| US-6300112-B1 | A RECOMBINANT ASPERGILLUS NIGER CELL CONTAINING A NUCLEOTIDE SEQUENCE ENCODING A PEPTIDE HAVING BETA.-XYLOSIDASE ACTIVITY; FOR USE AS SWEETNERS IN FOODS, CANDIES AND MEDICINES; BREAD IMPROVER, BEER BREWING, AND USED AS SUGAR SUBSTITUTE | DANISCO INGREDIENTS A.S (DANISCO A/S) (DK) | 2001-10-09 | — | — | US | disclosed |
| US-6177261-B1 | PROMOTER ACTIVATED BY REGULATOR AND LINKED TO DESIRED PROTEIN OR PEPTIDE AND A NUCLEOTIDE SEQUENCE INCLUDING A PROMOTER AND ENCODING THE REGULATOR; REGULATOR IS FUNGAL XYLANOLYTIC REGULATOR, XYLR; OBTAINING METABOLIC MUTANT MICROORGANISMS | DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) | 2001-01-23 | — | — | US | disclosed |
| EP-0907744-A1 | FUNGAL METALLO PROTEASE GENES | GIST-BROCADES B.V. (NL) | 1999-04-14 | — | — | EP | disclosed |
| EP-0833928-A1 | NOVEL BETA-XYLOSIDASE, NUCLEOTIDE SEQUENCE ENCODING IT, AND USE THEREOF | DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997046689-A1 | FUNGAL METALLO PROTEASE GENES | GIST-BROCADES B.V. (NL) | 1997-12-11 | — | — | WO | disclosed |
| WO-1997000964-A1 | NOVEL BETA-XYLOSIDASE, NUCLEOTIDE SEQUENCE ENCODING IT, AND USE THEREOF | DANISCO INGREDIENTS A/S (DANISCO A/S) (DK) | 1997-01-09 | — | — | WO | disclosed |
| US-5358864-A | DNA which codes for fungal endoxylanase | GIST-BROCADES, N.V. (NL) | 1994-10-25 | — | — | US | disclosed |
| WO-1992001793-A1 | CLONING AND EXPRESSION OF XYLANASE GENES FROM FUNGAL ORIGIN | GIST-BROCADES N.V. (NL) | 1992-02-06 | — | — | WO | disclosed |