Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197285 | 0.85 | AKR1B1 (0.33) | AKR1B1AKR1B10MAPTAKR1A1 | |
| SCHEMBL7648928 | 0.85 | MAP3K14 (0.35) | AKR1B1 | |
| SCHEMBL7650875 | 0.82 | MAP3K14 (0.31) | AKR1B1 | |
| SCHEMBL4373679 | 0.82 | APP (0.30) | — | |
| SCHEMBL7656329 | 0.80 | — | — | |
| SCHEMBL6668910 | 0.80 | RARA (0.45) | AKR1B1 | |
| SCHEMBL7679751 | 0.79 | — | — | |
| SCHEMBL4373634 | 0.77 | LMNA (0.42) | MAPT | |
| SCHEMBL9054289 | 0.77 | MAPT (0.41) | AKR1B1MAPT | |
| SCHEMBL9817651 | 0.77 | RARB (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592607-B | Application of covalent organic framework material of supported rhodium catalyst in alkyne polymerization | 北京理工大学 | 2023-06-20 | — | — | CN | claimed |
| CN-114702437-A | Sonogashira coupling method of heteroaryl phosphonium salt and terminal alkyne | 南京工业大学 | 2022-07-05 | — | — | CN | claimed |
| CN-111592607-B | Application of covalent organic framework material of supported rhodium catalyst in alkyne polymerization | 北京理工大学 | 2023-06-20 | — | — | CN | disclosed |
| CN-114702437-B | Sonogashira coupling method for heteroaryl phosphonium salt and terminal alkyne | 南京工业大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-116102483-A | Substituted pyrrole-2, 5-diketone compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2023-05-12 | — | — | CN | disclosed |
| CN-115974860-A | Retinoid compound, preparation method and application thereof, and pharmaceutical composition containing compound | 复旦大学附属中山医院 | 2023-04-18 | — | — | CN | disclosed |
| CN-115838382-A | Synthesis method of beta-ketophosphoric oxide | 惠州学院 | 2023-03-24 | — | — | CN | disclosed |
| CN-114702437-A | Sonogashira coupling method of heteroaryl phosphonium salt and terminal alkyne | 南京工业大学 | 2022-07-05 | — | — | CN | disclosed |
| CN-107176945-B | Retinoid compound, preparation method, intermediate and application thereof | 中国科学院上海有机化学研究所 | 2021-06-08 | — | — | CN | disclosed |
| US-20200216407-A1 | RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2020-07-09 | — | — | US | disclosed |
| US-10556879-B2 | Retinoid compound, preparation method therefor, intermediates thereof and application thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADMENY OF SCIENCES (CN) | 2020-02-11 | — | — | US | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| US-5716624-A | USEFUL FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, OPTHALMOLOGICAL DISORDERS, AS WELL AS MAMMALIAN SKIN AND HAIR CONDITIONS/DISORDERS | C.I.R.D. GALDERMA (FR) | 1998-02-10 | — | — | US | disclosed |
| US-5675033-A | FOR TREATMENT OF SKIN DISORDERS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |
| US-5663367-A | REGULATOR OF CELL PROLIFERATION AND DIFFERENTIATION; TREATMENT OF SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS | ALLERGAN (US) | 1997-09-02 | — | — | US | disclosed |
| US-5659042-A | Method for preparing esters of halonicotinic acids | ALLERGAN (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0788482-A1 | METHOD FOR PREPARING ESTERS OF HALONICOTINIC ACIDS | Allergan (US) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996039374-A1 | 2,4-PENTADIENOIC ACID DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-12-12 | — | — | WO | disclosed |
| WO-1996012701-A1 | METHOD FOR PREPARING ESTERS OF HALONICOTINIC ACIDS | ALLERGAN (US) | 1996-05-02 | — | — | WO | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556879-B2 | Retinoid compound, preparation method therefor, intermediates thereof and application thereof | RARA, RARB, RARG | AKR1B1 56/4885AKR1B10 97/4885MAPT 4836/4885 |
| US-20200216407-A1 | RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF | RARA, RARB, RARG | AKR1B1 56/4885AKR1B10 97/4885MAPT 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.