Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
| ▸ | FOS | P01100 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29031938 | 0.88 | CYP1A2 (0.59) | TSHRLMNAGAANFKB1CYP3A4 | |
| SCHEMBL8343609 | 0.85 | ATM (0.56) | CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL29638741 | 0.85 | ATM (0.56) | CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL29604390 | 0.81 | PTPN1 (0.82) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL17780116 | 0.81 | PTPN1 (0.82) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL9618618 | 0.80 | ALOX15 (0.55) | TAAR1TSHRMAPK1LMNAALOX5 | |
| SCHEMBL29740697 | 0.79 | PTPN1 (0.79) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL9281549 | 0.78 | TAAR1 (0.76) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL5072123 | 0.78 | TAAR1 (0.76) | TAAR1TSHRMAPK1LMNAGLA | |
| SCHEMBL11113382 | 0.78 | TSHR (0.61) | TAAR1TSHRMAPK1LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116063192-B | Synthesis method of dopamine hydrochloride | 武汉武药制药有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-116731005-B | PCSK9 small molecular protein degradation agent and preparation method and application thereof | 复旦大学 | 2024-04-16 | — | — | CN | disclosed |
| CN-116731005-A | PCSK9 small molecular protein degradation agent and preparation method and application thereof | 复旦大学 | 2023-09-12 | — | — | CN | disclosed |
| WO-2023165373-A1 | MICROMOLECULAR PCSK9 PROTEIN DEGRADATION AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF | 复旦大学 | 2023-09-07 | — | — | WO | disclosed |
| CN-116283654-A | Process for efficiently preparing dopamine hydrochloride bulk drug | 湖南恒生制药股份有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116063192-A | Synthesis method of dopamine hydrochloride | 武汉武药制药有限公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-3515891-B1 | SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS | MERCK SHARP & DOHME LLC (US) | 2023-03-08 | — | — | EP | disclosed |
| CN-111892507-B | Synthesis method of dopamine hydrochloride | 山东达冠医药科技有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-110511147-B | Method for reducing nitroolefin | 武汉嘉诺康医药技术有限公司 | 2022-06-17 | — | — | CN | disclosed |
| US-11008313-B2 | Substituted 1-methyl-1,2,3,4-tetrahydroisoquinoline molecules as PCSK9 allosteric binders | MERCK SHARP & DOHME CORP. (US) | 2021-05-18 | — | — | US | disclosed |
| EP-3515891-A1 | SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS | Merck Sharp & Dohme Corp. (US) | 2019-07-31 | — | — | EP | disclosed |
| WO-2018057409-A1 | SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS | MERCK SHARP & DOHME CORP. (US) | 2018-03-29 | — | — | WO | disclosed |
| WO-2018057409-A1 | SUBSTITUTED 1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE MOLECULES AS PCSK9 ALLOSTERIC BINDERS | MERCK SHARP & DOHME CORP. (US) | 2018-03-29 | — | — | WO | disclosed |
| US-7521579-B2 | Process for the preparation of alpha hydroxycarboxylic acid amides | SYNGENTA CROP PROTECTION, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521579-B2 | Process for the preparation of alpha hydroxycarboxylic acid amides | SYNGENTA CROP PROTECTION, INC. (US) | 2009-04-21 | — | — | US | disclosed |
| EP-1444195-B1 | PROCESS FOR THE PREPARATION OF ALPHA-HYDROXYCARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| EP-1526128-A2 | Process the preparation of alpha-hydroxycarboxylic acid amides | Syngenta Participations AG (CH) | 2005-04-27 | — | — | EP | disclosed |
| US-20050014950-A1 | Process for the preparation of alpha hydroxycarboxylic acid amides | SYNGENTA CROP PROTECTION, INC. | 2005-01-20 | — | — | US | disclosed |
| EP-1444195-A2 | PROCESS FOR THE PREPARATION OF ALPHA-HYDROXYCARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042166-A2 | PROCESS FOR PREPARATION OF α-HYDROXYCARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014950-A1 | Process for the preparation of alpha hydroxycarboxylic acid amides | HCAR1, HCAR3, HCAR2 | TAAR1 340/4885TSHR 2562/4885MAPK1 2366/4885 |
| US-11008313-B2 | Substituted 1-methyl-1,2,3,4-tetrahydroisoquinoline molecules as PCSK9 allosteric binders | PCSK9, PCSK7, LDLR | TAAR1 2767/4885TSHR 917/4885MAPK1 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.