Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 15/20 | 0.58 |
| ▸ | PPARG | P37231 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2007815 | 0.89 | LMNA (0.58) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL2002065 | 0.81 | PTGDR2 (0.53) | PLA2G2APPARGMEN1RGS12ALDH1A1 | |
| SCHEMBL8297277 | 0.81 | PLA2G2A (0.62) | PLA2G2APPARGMEN1RGS12ALDH1A1 | |
| SCHEMBL8300412 | 0.80 | PLA2G2A (0.77) | PLA2G2APPARGMEN1RGS12ALDH1A1 | |
| SCHEMBL4775976 | 0.80 | PTGDR2 (0.49) | PLA2G2APPARGMAPT | |
| SCHEMBL8296288 | 0.80 | PLA2G2A (0.64) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL8291681 | 0.79 | PLA2G2A (0.82) | PLA2G2A | |
| SCHEMBL8292072 | 0.78 | PLA2G2A (0.61) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL3000306 | 0.78 | PTGDR2 (0.68) | PLA2G2AMEN1RGS12ALDH1A1LMNA | |
| SCHEMBL8645800 | 0.78 | CNR2 (0.55) | PLA2G2AMEN1RGS12ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610244-A1 | Indole compounds | Ironwood Pharmaceuticals, Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |