Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 2/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790078 | 0.78 | KDM4E (0.44) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL6598506 | 0.78 | NPSR1 (0.48) | KDM4EMAPTALDH1A1GAAPOLB | |
| SCHEMBL4377125 | 0.77 | ALDH1A1 (0.56) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL4153078 | 0.77 | SCN9A (0.43) | KDM4EMAPTALDH1A1LMNAPTPRC | |
| Hydrochloric Acid SCHEMBL25433125 | 0.77 | PTPRC (0.41) | KDM4EMAPTALDH1A1PTPRCHSPA5 | |
| SCHEMBL13527534 | 0.77 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL4147701 | 0.77 | LMNA (0.46) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL30745582 | 0.76 | HDAC3 (0.49) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL10713936 | 0.75 | ALDH1A1 (0.59) | KDM4EMAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL3713890 | 0.75 | AKR1C4 (0.60) | KDM4EMAPTALDH1A1RECQLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | claimed |
| EP-2665709-B1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RES CO LTD (IN) | 2016-12-07 | — | — | EP | disclosed |
| EP-2665709-B1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RES CO LTD (IN) | 2016-12-07 | — | — | EP | disclosed |
| US-9024021-B2 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2015-05-05 | — | — | US | disclosed |
| US-9024021-B2 | Diarylacetylene hydrazide containing tyrosine kinase inhibitors | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2015-05-05 | — | — | US | disclosed |
| EP-2665709-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | Sun Pharma Advanced Research Company Limited (IN) | 2013-11-27 | — | — | EP | disclosed |
| US-20130296557-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| US-20130296557-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2013-11-07 | — | — | US | disclosed |
| WO-2012098416-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098416-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2012-07-26 | — | — | WO | disclosed |
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | disclosed |
| WO-2009109991-A2 | NOVEL HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD., (IN) | 2009-09-11 | — | — | WO | disclosed |
| EP-0709372-B1 | N-arylthiohydrazone derivatives as insecticidal and acaricidal agents | AMERICAN CYANAMID CO (US) | 1998-08-26 | — | — | EP | disclosed |
| US-5556885-A | N-aryl- and N-heteroarylhydrazones of substituted thioacids and the s-oxides thereof as insecticidal and acaricidal agents | AMERICAN CYANAMID COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0709372-A1 | N-arylthiohydrazone derivatives as insecticidal and acaricidal agents | American Cyanamid Company (US) | 1996-05-01 | — | — | EP | disclosed |
| US-4309422-A | INSECTICIDES | VELSICOL CHEMICAL CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4094906-A | INSECTICIDES AND MITICIDES | THE UPJOHN COMPANY (US) | 1978-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130296557-A1 | DIARYLACETYLENE HYDRAZIDE CONTAINING TYROSINE KINASE INHIBITORS | ABL1, LCK, JAK2 | KDM4E 895/4885MAPT 1810/4885ALDH1A1 643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.