Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880854 | 1.00 | CES2 (0.46) | CES2MAPTSMN1; SMN2KDM4EACHE | |
| SCHEMBL5307396 | 0.81 | ALDH1A1 (0.40) | MAPTSMN1; SMN2HCAR1APPGRIN2D | |
| SCHEMBL30292169 | 0.81 | ALDH1A1 (0.40) | MAPTSMN1; SMN2HCAR1APPGRIN2D | |
| SCHEMBL13548653 | 0.81 | PDE2A (0.42) | CES2MAPTSMN1; SMN2KDM4EACHE | |
| SCHEMBL5307395 | 0.81 | ALDH1A1 (0.40) | MAPTSMN1; SMN2HCAR1APPGRIN2D | |
| SCHEMBL13707569 | 0.80 | PDE2A (0.45) | MAPTSMN1; SMN2KDM4EGRIN2DGRIN3B | |
| SCHEMBL7806209 | 0.80 | HPGD (0.44) | MAPTKDM4EHCAR1APPGRIN2D | |
| SCHEMBL1436520 | 0.80 | HPGD (0.44) | MAPTSMN1; SMN2HCAR1APPGRIN2D | |
| SCHEMBL4373756 | 0.80 | PDE2A (0.45) | MAPTSMN1; SMN2KDM4EGRIN2DGRIN3B | |
| SCHEMBL1436519 | 0.80 | HPGD (0.44) | MAPTSMN1; SMN2HCAR1APPGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546254-A1 | Imidazo[4,5-C]pyridine compounds and methods of antiviral treatment | K.U.Leuven Research & Development (BE) | 2013-01-16 | — | — | EP | disclosed |
| US-8329727-B2 | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment | GILEAD SCIENCES, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-1706403-B9 | IMIDAZO[4,5-C]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | LEUVEN K U RES & DEV (BE) | 2012-07-25 | — | — | EP | disclosed |
| EP-1706403-B1 | IMIDAZO[4,5-C]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | LEUVEN K U RES & DEV (BE) | 2012-02-08 | — | — | EP | disclosed |
| US-7795276-B2 | Imiadazo[4,5-c] pyridine compound and method of antiviral treatment | GILEAD SCIENCES, INC. (US) | 2010-09-14 | — | — | US | disclosed |
| EP-2161273-A1 | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment | K.U.Leuven Research & Development (BE) | 2010-03-10 | — | — | EP | disclosed |
| US-20100028301-A1 | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-02-04 | — | — | US | disclosed |
| US-7648998-B2 | 5-((3-(4-chlorophenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine; hepatitis-C-virus | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2010-01-19 | — | — | US | disclosed |
| EP-1841765-B1 | IMIDAZO[4,5-C]PYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20080255202-A1 | Phenylthioacetic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-10-16 | — | — | US | disclosed |
| US-20080188516-A1 | IMIADAZO[4,5-C] PYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2008-08-07 | — | — | US | disclosed |
| US-20070244148-A1 | Imidazo 4,5-C Pyridine Compounds and Methods of Antiviral Treatment | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2007-10-18 | — | — | US | disclosed |
| EP-1841765-A2 | IMIDAZO[4,5-C]PYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2007-10-10 | — | — | EP | disclosed |
| EP-1742942-A1 | PHENYLTHIOACETIC ACID DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2007-01-17 | — | — | EP | disclosed |
| US-20060252791-A1 | Imidazo[4,5-c]pyridine compound and method of antiviral treatment | GILEAD SCIENCES, INC. | 2006-11-09 | — | — | US | disclosed |
| EP-1706403-A2 | IMIDAZO[4,5-C]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | K.U.Leuven Research & Development (BE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2006069193-A2 | IMIDAZO[4,5-C]PYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| WO-2005097784-A1 | PHENYLTHIOACETIC ACID DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | WO | disclosed |
| US-20050222198-A1 | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment | K.U. LEUVEN RESEARCH & DEVELOPMENT, GERHARD PUERSTINGER AND GILEAD SCIENCES, INC. | 2005-10-06 | — | — | US | disclosed |
| WO-2005063744-A2 | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | K.U. LEUVEN RESEARCH & DEVELOPMENT (BE) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188516-A1 | IMIADAZO[4,5-C] PYRIDINE COMPOUND AND METHOD OF ANTIVIRAL TREATMENT | MAVS, IRF3, IPO4 | CES2 1984/4885MAPT 2199/4885SMN1; SMN2 356/4885 |
| US-20060252791-A1 | Imidazo[4,5-c]pyridine compound and method of antiviral treatment | MAVS, ZC3HAV1, ZC3HAV1L | CES2 1318/4885MAPT 2194/4885SMN1; SMN2 1023/4885 |
| US-20100028301-A1 | IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT | CYP3A5, TPMT, ZC3HAV1 | CES2 515/4885MAPT 4389/4885SMN1; SMN2 2150/4885 |
| US-20070244148-A1 | Imidazo 4,5-C Pyridine Compounds and Methods of Antiviral Treatment | ZC3HAV1, TPMT, DPP4 | CES2 1038/4885MAPT 4159/4885SMN1; SMN2 2893/4885 |
| US-20050222198-A1 | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment | CYP3A5, TPMT, TYMP | CES2 484/4885MAPT 4436/4885SMN1; SMN2 1956/4885 |
| US-20080255202-A1 | Phenylthioacetic Acid Derivatives and Use Thereof | PAH, TST, MPST | CES2 1588/4885MAPT 1228/4885SMN1; SMN2 4675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.