Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.71 |
| ▸ | PDE4A | P27815 | 13/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | VEGFA | P15692 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | PDE5A | O76074 | 1/20 | 0.71 |
| ▸ | TNF | P01375 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PDE1A | P54750 | 1/20 | 0.71 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28332849 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL4373919 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL28332840 | 1.00 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL28352179 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL6053887 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL6053885 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL29623773 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL29623500 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL1134133 | 0.87 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| S-Rolipram SCHEMBL5321568 | 0.83 | PDE4A (1.00) | PDE4BPDE4APDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305329-B2 | 6.ALPHA.,9.ALPHA.-DIFLUORO-17.ALPHA.-(2-FURANYLCARBOXYL)OXY-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT | GLAXO GROUP LTD (GB) | 2015-03-18 | — | — | EP | claimed |
| EP-1305329-B1 | 6.ALPHA.,9.ALPHA.-DIFLUORO-17.ALPHA.-(2-FURANYLCARBOXYL)OXY-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3-OXO-ANDROST-1,4-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT | GLAXO GROUP LTD (GB) | 2007-12-05 | — | — | EP | claimed |
| CN-106279110-B | heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | 勃林格殷格翰国际有限公司 | 2019-12-10 | — | — | CN | disclosed |
| EP-2091571-A2 | METHOD FOR STERILIZING A FILM CONTAINER | Boehringer Ingelheim International GmbH (DE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008049915-A2 | METHOD FOR STERILIZING A FILM CONTAINER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-05-02 | — | — | WO | disclosed |
| EP-1896026-A2 | PROCESS FOR PREPARING TIOTROPIUM SALTS, TIOTROPIUM SALTS AS SUCH AND PHARMACEUTICAL COMPOSITIONS THEREOF | Boehringer Ingelheim International GmbH (DE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006134021-A2 | PROCESS FOR PREPARING TIOTROPIUM SALTS, TIOTROPIUM SALTS AS SUCH AND PHARMACEUTICAL COMPOSITIONS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |
| US-20060035877-A1 | Method and compositions for treating pulmonary diseases | GOODFELLOW PETER N | 2006-02-16 | — | — | US | disclosed |
| US-20040028615-A1 | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents | GLAXOSMITHKLINE INTELLECTUAL PROPERTY MANAGEMENT LIMITED (GB) | 2004-02-12 | — | — | US | disclosed |
| WO-2003048181-A1 | 17.ALPHA. -CYCLIC ESTERS OF 16-METHYLPREGNAN-3,20-DIONE AS ANTI-INFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040028615-A1 | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents | HSD17B1, HSD17B7, HSD3B1 | PDE4B 3401/4885PDE4A 2770/4885PDE4C 3749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.