Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583064 | 0.86 | MAPT (0.64) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL3536004 | 0.85 | MAPT (0.65) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL26340070 | 0.81 | HPGD (0.66) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL4379759 | 0.81 | CXCR2 (0.42) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL4381941 | 0.81 | MAPT (0.74) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL4375736 | 0.80 | ALDH1A1 (0.53) | HPGDMAPTLMNAMEN1KMT2A | |
| SCHEMBL4716438 | 0.78 | DAO (0.42) | DAO | |
| SCHEMBL4373932 | 0.78 | CXCR2 (0.54) | HPGDLMNATSHR | |
| SCHEMBL20867850 | 0.73 | MMP13 (0.45) | HPGDMAPTLMNACYP1A2CYP2C9 | |
| SCHEMBL20867969 | 0.72 | HPGD (0.43) | HPGDMAPTLMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686119-B1 | Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors | SMITHKLINE BEECHAM PLC (GB) | 2009-07-29 | — | — | EP | disclosed |
| EP-1263740-B1 | PYRIMIDINE-4-ONE DERIVATIVE AS LDL-PLA2 INHIBITOR | SMITHKLINE BEECHAM PLC (GB) | 2006-07-19 | — | — | EP | disclosed |