Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTGFR | P43088 | 1/20 | 0.31 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527025 | 0.74 | FSHR (0.56) | TSHRNPSR1KMT2A | |
| SCHEMBL4373967 | 0.73 | TSHR (0.34) | MAPTTSHRAKR1C4AKR1C3AKR1C2 | |
| SCHEMBL3525924 | 0.73 | GAA (0.34) | MAPTTSHRHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL1322915 | 0.64 | FSHR (0.69) | TSHRNPSR1KMT2A | |
| SCHEMBL3524786 | 0.64 | MAPT (0.42) | MAPTALDH1A1TP53LMNAPOLB | |
| SCHEMBL1323012 | 0.61 | APEX1 (0.58) | MAPTAKR1C4AKR1C3AKR1C2AKR1C1 | |
| SCHEMBL4367941 | 0.59 | FSHR (0.64) | TSHRNPSR1KMT2A | |
| SCHEMBL28530907 | 0.59 | ALDH1A1 (0.51) | MAPTAKR1C3AKR1C2ALDH1A1LMNA | |
| SCHEMBL224447 | 0.58 | HCRTR1 (0.36) | MAPTTSHRHCRTR1HCRTR2TP53 | |
| SCHEMBL336750 | 0.57 | MAPT (0.68) | MAPTAKR1C4AKR1C3AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |