Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.31 |
| ▸ | FSHR | P23945 | 1/20 | 0.30 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.30 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.30 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4373972 | 0.73 | MAPT (0.36) | TSHRMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3527025 | 0.71 | FSHR (0.56) | TSHRFSHR | |
| SCHEMBL3524786 | 0.63 | MAPT (0.42) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL1322915 | 0.63 | FSHR (0.69) | TSHRFSHR | |
| SCHEMBL1307640 | 0.59 | ALDH1A1 (0.60) | TSHRMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3525924 | 0.58 | GAA (0.34) | TSHRMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL31642632 | 0.57 | MAPT (0.72) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL28530907 | 0.56 | ALDH1A1 (0.51) | MAPTALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL1323012 | 0.56 | APEX1 (0.58) | MAPTALDH1A1KDM4EAKR1C4AKR1C3 | |
| SCHEMBL29978583 | 0.55 | MAPT (0.70) | TSHRMAPTRAB9AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578726-B1 | TETRAHYDROQUINOLINE DERIVATIVES | ORGANON NV (NL) | 2009-02-25 | — | — | EP | disclosed |