SCHEMBL4374138

SCHEMBL4374138

C=CC(=O)NC(O)(CO)CO

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
TSHR P16473 2/20 0.42
MAPK1 P28482 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
CYP3A4 P08684 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
TP53 P04637 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HIF1A Q16665 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
ZDHHC20 Q5W0Z9 1/20 0.32
ZDHHC2 Q9UIJ5 1/20 0.32
TGM2 P21980 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9328483 0.81 ALDH1A1 (0.42) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL3235326 0.78 ALDH1A1 (0.44) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL105869 0.78 ALDH1A1 (0.44) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL7617237 0.74 ALDH1A1 (0.44) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL7612005 0.74 ALDH1A1 (0.53) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL27961654 0.74 ALDH1A1 (0.43) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL976113 0.74
SCHEMBL150557 0.73 TSHR (0.39) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL1350125 0.71 TSHR (0.41) ALDH1A1TSHRMAPK1TDP1CYP3A4
SCHEMBL275376 0.71 ALDH1A1 (0.39) ALDH1A1TSHRMAPK1TDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050209100-A1 Optically active support materials, their method of preparation and their uses EKA CHEMICALS (SE) 2005-09-22 US claimed
EP-1458475-A2 OPTICALLY ACTIVE SUPPORT MATERIALS, METHOD FOR PREPARING SAME AND USES THEREOF Eka Chemicals AB (SE) 2004-09-22 EP claimed
WO-2003055594-A2 OPTICALLY ACTIVE SUPPORT MATERIALS, METHOD FOR PREPARING SAME AND USES THEREOF EKA CHEMICALS AB (SE) 2003-07-10 WO claimed
EP-0407033-A2 Lipase and isozymes, notably of Candida rugosa, and their use RHONE-POULENC INC. (US) 1991-01-09 EP claimed
WO-1990015146-A1 ENZYMES AND THEIR USE RHONE-POULENC INC. (US) 1990-12-13 WO claimed
US-10975350-B2 Cell culture substrate and method of making thereof AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2021-04-13 US disclosed
US-7597804-B2 Optically active support materials, their method of preparation and their uses EKA CHEMICALS (SE) 2009-10-06 US disclosed
US-20050209100-A1 Optically active support materials, their method of preparation and their uses EKA CHEMICALS (SE) 2005-09-22 US disclosed
EP-1458475-A2 OPTICALLY ACTIVE SUPPORT MATERIALS, METHOD FOR PREPARING SAME AND USES THEREOF Eka Chemicals AB (SE) 2004-09-22 EP disclosed
WO-2003055594-A2 OPTICALLY ACTIVE SUPPORT MATERIALS, METHOD FOR PREPARING SAME AND USES THEREOF EKA CHEMICALS AB (SE) 2003-07-10 WO disclosed