Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | NPR1 | P16066 | 1/20 | 0.45 |
| ▸ | OGG1 | O15527 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375683 | 0.82 | HTR7 (0.56) | HTR7LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL4375545 | 0.81 | HTR7 (0.54) | HTR7LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL7006351 | 0.80 | HTR7 (0.61) | HTR7LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL4375523 | 0.76 | HTR7 (0.56) | HTR7MAPTL3MBTL1NPSR1SLC2A1 | |
| SCHEMBL7014074 | 0.76 | HTR7 (0.54) | HTR7MAPTL3MBTL1NPSR1SLC2A1 | |
| SCHEMBL4381740 | 0.74 | HTR7 (0.49) | HTR7LMNAMAPTKDM4EPOLB | |
| SCHEMBL7006329 | 0.74 | F7 (0.44) | HTR7NPR1MAPTHTTNPC1 | |
| SCHEMBL4374959 | 0.72 | NPC1 (0.45) | HTR7NPR1MAPTHTTNPC1 | |
| SCHEMBL7013657 | 0.72 | HTR7 (0.48) | HTR7MAPTL3MBTL1NPSR1SLC2A1 | |
| SCHEMBL7006872 | 0.71 | HTR7 (0.81) | HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | claimed |
| EP-1280781-A4 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2003-08-06 | — | — | EP | claimed |
| EP-1280781-A1 | 5-HT 7 RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085701-A1 | 5-HT7 RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-15 | — | — | WO | claimed |
| EP-1280781-B1 | 5-HT 7 RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2009-11-18 | — | — | EP | disclosed |